Cyclotron for PET Radiopharmaceuticals

描述(由申请人提供)：为了有效地合成用于正电子发射断层扫描(PET)的短寿命新的放射性示踪剂，新的回旋加速器是必不可少的。加州大学欧文分校(UCI)的MC-17回旋加速器已有20多年的历史，目前不足以满足NIH资助的各种研究人员对动物和人类PET成像的需求。除了氟-18之外，它无法提供任何数量可观的其他短期同位素。具有高比活度、高放射化学产率和高可靠性的独特的PET放射性示踪剂的可用性将加强UCI正在进行的动物和人类PET研究。与现有的高分辨率Inveon microPET/MicroCT和人体PET和PET/CT扫描仪相结合，它将允许进行多模式成像，以比UCI更详细地研究生理和生化机制。UCI的放射科学、精神病学和人类行为学、药理学、生理学和生物物理学、外科、解剖学和神经生物学、神经生物学和行为学、生物化学、医学、整形外科、生物医学工程、放射性药物实验室都参与了使用成像方法来研究正常和异常的生理过程。UCI的研究人员在各种条件下的动物和人体研究中使用成像技术有着悠久的传统，UCI各个中心和部门的大量研究人员参与了动物模型的研究。收购新的回旋加速器将使众多项目的研究人员能够研究活体动物模型，并协助将研究转化为人类PET研究。UCI的研究人员与高分辨率PET一起，将能够准确评估神经科学、肿瘤学、心脏病学和其他应用中的假说。UCI的影像研究是独一无二的，因为基础动物研究中的研究人员与转译临床研究密切相关 在各种节目中都得到了体现。对各科室招收的本科生、研究生、医学生和住院医师进行影像方面的培训。根据与成像相关的课程和论文工作的水平，每个学生的教育、培训和经验的程度从2个月到4年不等。新的回旋加速器将是他们教育和培训的组成部分。回旋加速器将由Jogesh Mukherjee博士指导。来自四个不同部门(放射科学、医学、药理学、神经生物学和行为学)的团队将为新回旋加速器的有效运行和最大限度地利用提供必要的管理、科学和技术专业知识。

DESCRIPTION (provided by applicant): A new Cyclotron is essential in order to efficiently synthesize short-lived new and novel radiotracers for positron emission tomography (PET). The MC-17 cyclotron at University of California-Irvine (UCI) is over 20 years old, and is currently inadequate to meet the needs of the various NIH funded investigators for animal and human PET imaging. It is unable to provide any significant amounts of other short-lived isotopes apart from fluorine-18. The availability of unique PET radiotracers in high specific activity, radiochemical yield and reliably will enhance ongoing animal and human PET research at UCI. In association with an existing high resolution Inveon MicroPET/MicroCT and human PET and PET/CT scanners it will allow multi-modality imaging for the study of physiology and biochemical mechanisms with greater detail than has been possible at UCI. Departments of Radiological Sciences, Psychiatry and Human Behavior, Pharmacology, Physiology and Biophysics, Surgery, Anatomy and Neurobiology, Neurobiology and Behavior, Biological Chemistry, Medicine, Orthopedic Surgery, Biomedical Engineering, Radiopharmaceutical Laboratories at UCI have been involved in using imaging methodology to study normal and abnormal physiological processes. Researchers at UCI have a long tradition of using imaging in animal and human studies of various conditions and a large number of researchers at the various centers and Departments in UCI are involved in studying animal models. The acquisition of the new cyclotron will allow researchers in numerous projects to study in vivo animal models and assist in translational research to human PET studies. Investigators at UCI in conjunction with the high resolution PET will be able to accurately assess hypothesis in neurosciences, oncology, cardiology and other applications. Imaging research at UCI is unique in terms of the close association of investigators in basic animal research with translational clinical research as exemplified in the various programs. Undergraduate, graduate students, medical students and residents enrolled in various departments are trained in imaging. The degree of education, training and experience vary between 2 months to 4 years for each student based on the level of courses and thesis work related to imaging. The new cyclotron will be an integral part of their education and training. The cyclotron will be under the direction of Dr. Jogesh Mukherjee. A team from four different departments (Radiological Sciences, Medicine, Pharmacology, Neurobiology & Behavior) will provide administrative, scientific, and technical expertise necessary for the effective operation and maximal utilization of the new cyclotron.