Modulation of neuronal excitability

在本财年，我们对一款正在开发中的床垫进行了重大改进，该床垫可以监测婴儿的呼吸暂停，并打开床垫中类似噪音的低水平振动，从而在不吵醒婴儿的情况下从呼吸暂停切换到真呼吸暂停。 帕金森项目的初步结果表明，在植入脑深部刺激(DBS)电极后，低水平的电气噪声足以导致手术室中的患者在非震颤和震颤状态之间立即转换。震颤的抑制是使用由传统DBS设备施加的矩形电流脉冲来产生的。更多的实验有望在不需要传统的DBS设备的情况下，演示由噪音引起的从颤动状态到非颤动状态的转变。

During the current fiscal year we have made significant improvements in a mattress in development that monitors apnea in infants and turns on low-level noise-like vibrations in the mattress that produce a switch from apnea to eupnea without waking the infant. Preliminary results in the Parkinson's project have shown that low level electrical noise is sufficient to cause transitions between the non-tremor and the tremor state in patients in the surgical suite immediately after a Deep Brain Stimulation (DBS) electrode has been implanted. Suppression of the tremor was produced using rectangular current pulses administered by a traditional DBS device. Additional experiments will, hopefully, demonstrate noise-induced transitions from the tremor to the non-tremor state without need of the traditional DBS device.