Overall Objectives and ADM

这是波多黎各大学(UPR)和德克萨斯大学MD Anderson癌症中心(MDACC)之间的癌症研究卓越伙伴关系(伙伴关系)第二次竞争性续签的申请，这两个机构有一个共同的愿景，即消除波多黎各、休斯顿和拉丁美洲缺乏服务的社区和社会经济弱势群体中的癌症健康差距。这一申请代表了一种真正的合作伙伴关系，在创建和实施完全整合的团队科学、外展、培训、职业发展和教育计划方面，两家机构都从独特的专业知识和互惠互利中受益。作为国家癌症研究所(NCI)值得注意的承诺和投资的延续，该申请旨在将波多黎各大学综合癌症中心(UPRCCC)*提升到与其他国家癌症项目同等的竞争水平，本申请概述了以下步骤：1)巩固、加强和扩大UPR和MDACC之间的关系；2)将UPRCCC转变为一个独立运作和自我维持的机构。如果没有这种长期、协同的伙伴关系作为变革的催化剂，到目前为止实现的一些目标将需要数年时间才能实现：其他目标甚至不可能实现。这项推进伙伴关系的申请的关键要素包括： ？跟踪和评价伙伴关系成果的循证逻辑模型方法(C节)； 根据NCI翻译研究工作组的说法，代表翻译研究连续体(T1至T3)阶段的多学科协作研究项目(D部分)； ？以癌症为重点的综合培训和职业发展核心(E部分)，以吸引、吸引和留住受训人员和初级教员，作为UPRCCC未来教员职位培训渠道的一部分； ？开发新的教育课程--癌症医学、科学和健康差距的核心课程(E.2节)，以提高现有和未来的临床医生、科学家和内科科学家的知识、技能和文化能力； ？外联努力(F部分)，以建设社区执行和可持续执行癌症控制方案的能力；以及 ？生物统计学、流行病学和生物信息学核心(G部分)，对上次更新期间开发的现有基础设施进行补充和改进。 为了促进普遍定期审议和普遍定期审议方案向独立的过渡，普遍定期审议和普遍定期审议方案在MDACPIS的全力支持下，在制定具体目标方面发挥了领导作用。在接下来的五年里，两个机构都认识到，虽然伙伴关系仍将是一项共同努力，但普遍定期审议和普遍定期定期审议项目将迫切需要推动发展、推进和倡导普遍定期审议委员会在研究、培训、教育和外展方面以癌症为重点的使命。因此，考虑到U54标准的目标，衡量这一伙伴关系在这次更新结束时是否成功的一个关键结果是，UPRCCC是否做好了充分的准备，并处于领先地位，以应对影响整个癌症连续体(预防、早期发现、诊断、治疗和生存)的不平等癌症负担。

This is an application for the 2nd competitive renewal ofthe Partnership for Excellence in Cancer Research (Partnership) between the University of Puerto Rico (UPR) and the University of Texas MD Anderson Cancer Center (MDACC), two institutions which share a singular vision to eradicate cancer health disparities in underserved communities and socio-economically disadvantaged populations in Puerto Rico, Houston, and Latin America in general. This application represents a true partnership in which both institutions profit from distinct expertise and mutual benefits in the creation and implementation of fully integrated team science, outreach, training, career development, and education initiatives. As a continuation of the National Cancer Institute's (NCI) noteworthy commitment and investment to elevate the University of Puerto Rico Comprehensive Cancer Center (UPRCCC)* to a competitive level on par with other national cancer programs, this application outlines steps to: 1) solidify, strengthen and expand the relationship between UPR and MDACC and 2) transition the UPRCCC into an independently-functioning and self-sustaining institution. Without this long-standing, synergistic partnership as a catalyst for change, some of the objectives met thus far would have taken years to accomplish: other objectives would not have even been possible. Key elements of this application to advance the Partnership include: ¿ An evidence-based logic model approach (Section C) for tracking and evaluating Partnership outcomes; ¿ Multidisciplinary collaborative research projects (Section D) that represent stages of the translational research continuum (Tl to T3) according to NCI's Translational Research Working Group; ¿ A comprehensive cancer-focused training and career development core (Section E) to attract, engage and retain trainees and junior faculty as part of a training pipeline for future faculty positions with the UPRCCC; ¿ The development of a new educational curriculum, Core Curriculum in Cancer Medicine, Science, and Health Disparities, (Section E.2) to enhance the knowledge, skills and cultural competencies of current and future clinicians, scientists and physician-scientists; ¿ Outreach efforts (Section F) to build community capacity for the implementation and sustainability of cancer control programs; and ¿ A Biostatistics, Epidemiology and Bioinformatics Core (Section G), which augments and improves upon existing infrastructure developed during the last renewal. To facilitate the UPRCCC's transition towards independence, UPR and UPRCCC Pis took on a leadership role in developing the specific aims with the full support of the MDACC Pis. Over the next five years, both institutions recognize that while the Partnership will remain a joint effort, it will become imperative for the UPR and UPRCCC Pis to give impetus to developing, advancing, and advocating the UPRCCC's cancer-focused missions in research, training, education, and outreach. Therefore, with the goals ofthe U54 PAR in mind, a critical outcome to measure the success of this Partnership at the end of this renewal is whether or not the UPRCCC is sufficiently prepared and positioned to become a frontrunner in addressing the unequal burden of cancer that effects Hispanic populations across the cancer continuum (prevention, early detection, diagnosis, treatment and survivorship).