Biostatistics, Epidemiology, and Bioinformatics Core (BEBiC)

生物统计学、流行病学和生物信息学核心 (BEBiC)

• 批准号: 8754434
• 负责人: Michelle Ann Barton
• 金额: $ 15.89万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8754434
• 关键词: Algorithms; Basic Science; Bioinformatics; Biometry; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Confidentiality of Patient Information; Consultations; Data; Data Analyses; Data Collection; Data Quality; Data Security; Educational workshop; Ensure; Epidemiologic Studies; Epidemiology; Experimental Designs; Future; Genomics; Grant; Human Resources; Laboratories; Manuscripts; Mentors; Methodology; Modeling; Pilot Projects; Process; Publications; Publishing; Quality Control; Reporting; Research; Research Design; Research Personnel; Resources; Sample Size; Single Nucleotide Polymorphism; Staging; Statistical Data Interpretation; Statistical Methods; Suggestion; Survival Analysis; System; Testing; Translational Research; University of Texas M D Anderson Cancer Center; Writing; anticancer research; data acquisition; data integration; data management; design; innovation; investigator training; meetings; outreach program; pre-clinical; programs; prospective; research study; sound; statistics

The Biostatistics, Epidemiology and Bioinformatics Gore (BEBiC) will provide professional expertise in biostatistics, epidemiology and bioinformatics for all research studies within the Partnership. The Gore will be a comprehensive, multilateral resource for data acquisition and management, design of laboratory experiments, epidemiological studies and clinical trials, statistical analysis, and publishing translational research generated by the Partnership. The BEBiC will incorporate sound experimental design principles within all projects and programs; carry out data analyses using appropriate statistical methodology; and contribute to interpretation of results through written reports and frequent interaction with project and program co-leaders. The Core will provide an integrated data management system to facilitate communication among all projects and cores, which will be customized to meet the needs ofthe Partnership. This process includes prospective data collection, data quality control, data security, and patient confidentiality. Thus, from inception to reporting, projects and programs will benefit from collaboration with the BEBiC. In addition, the BEBIC will organize different workshops related with the statistical and bioinformatics needs for every research study, particularly with all types of regression modeling and variable selection, survival analysis and optimization of dynamic treatment regimes, clinical trials, sample size, power calculations and statistics and algorithms for bioinformatics. Also, the BEBiC's personnel will develop new statistical methodologies in cancer research according to the projects needs.

生物统计学、流行病学和生物信息学戈尔（BEBiC）将为伙伴关系内的所有研究提供生物统计学、流行病学和生物信息学方面的专业知识。戈尔将是一个全面的多边资源，用于数据采集和管理、实验室实验设计、流行病学研究和临床试验、统计分析以及出版伙伴关系产生的转化研究。BEBiC将在所有项目和计划中纳入合理的实验设计原则;使用适当的统计方法进行数据分析;并通过书面报告以及与项目和计划共同领导人的频繁互动来解释结果。该核心将提供一个综合数据管理系统，以便利所有项目和核心之间的通信，该系统将根据伙伴关系的需要进行定制。该过程包括前瞻性数据收集、数据质量控制、数据安全和患者保密。因此，从开始到报告，项目和计划将受益于与BEBiC的合作。此外，BEBIC将组织与每项研究的统计和生物信息学需求相关的不同研讨会，特别是所有类型的回归建模和变量选择，生存分析和动态治疗方案的优化，临床试验，样本量，功效计算和统计以及生物信息学算法。此外，BEBiC的工作人员将根据项目的需要开发癌症研究的新统计方法。