The Simultaneous Acquisition of Auditory Transient and Steady State Evoked Potent

描述（由申请人提供）：本项目旨在开发一种能够使用高效和先进的处理技术同时采集瞬态和稳态听觉诱发电位（AEP）的设备。所提出的技术将被实现为智能听力系统（IHS）诱发电位系统平台上的软件模块。听觉瞬态响应（ATR）通常使用短持续时间刺激引起，并且包括听觉脑干响应（ABR）、中潜伏期响应（MLR）和晚潜伏期响应（LLR）。听觉稳态反应（ASSR）是使用长时间刺激引起的，代表连续的诱发活动。目前，ATR和ASSR数据是独立记录的，使用不同的软件模块或不同的设备，并独立分析和呈现结果数据。因此，测试时间延长，并且由于测试之间的刺激技术、校准和患者状态的差异，可能难以协调数据。智能听力系统开发了一种同时获取ATR和ASSR的新方法。该技术使用特殊刺激序列的集合，这些集合可以被去卷积以提取ATR，同时将集合平均在一起产生真正的ASSR。与以前的反卷积技术，如最大长度序列（MLS），需要复杂的非周期性刺激的反卷积，所提出的技术使用最近开发的方法，连续循环平均反卷积（CLAD），它利用近等同步序列。通过组合多组几乎等同步的序列，实现了ATR和ASSR的同时获取。同时获取ATR和ASSR的好处有很多：1）提供每种类型反应的独特信息，而不增加测试时间，2）消除记录程序之间的患者状态差异，3）消除与使用不同刺激和校准相关的问题，以及4）促进解释 通过在一个用户界面上提供所有结果，在第一阶段，将进行工作，以优化和测试拟议的同时技术，通过比较结果与传统的ATR和ASSR使用点击和频率特定的刺激10个年轻的成年人。在第二阶段，这项工作将扩大，并进行更大规模的临床研究，包括各种听力损失配置的婴儿和成人。该设备预计将立即具有商业化潜力，作为数千名当前IHS用户和新的潜在用户的附加软件模块。

DESCRIPTION (provided by applicant): This project aims to develop a device capable of acquiring transient and steady state auditory evoked potenlatials (AEPs) simultaneously using an efficient and advanced processing technique. The proposed technique will be implemented as a software module on Intelligent Hearing Systems' (IHS) evoked potential system platform. Auditory Transient Responses (ATRs) are typically elicited using short duration stimuli and include Auditory Brainstem Responses (ABRs), Middle Latency Responses (MLRs) and Late Latency Responses (LLRs). Auditory Steady State Responses (ASSRs) are elicited using long duration stimuli and represent continuous evoked activity. Currently, ATR and ASSR data are recorded independently, using either different software modules or different devices, and the resulting data are analyzed and presented independently. As a result, testing time is prolonged and it may be difficult to reconcile data because of differences in stimulation technique, calibration and patient status between tests. A new method of acquiring ATRs and ASSRs simultaneously has been developed by Intelligent Hearing Systems. The technique uses sets of special stimulation sequences that can be deconvolved to extract ATRs while averaging the sets together results in true ASSRs. Unlike previous deconvolution techniques, such as Maximum Length Sequences (MLS), which required complex non-periodic stimuli for deconvolution, the proposed technique uses a more recently developed method, Continuous Loop Averaging Deconvolution (CLAD), which utilizes nearly isosynchronous sequences. By combining sets of nearly isosynchrnous sequences, the simultaneous acquisition of ATRs and ASSRs is accomplished. The benefits of acquiring both ATRs and ASSRs simultaneously are numerous: 1) Provide unique information from each type of response without increasing test time, 2) Eliminate patient state differences between recording procedures, 3) Eliminate problems associated with use of different stimuli and calibration, and 4) Facilitate interpretation of data by providing all results on one user interface. During Phase I, work will be conducted to optimize and test the proposed simultaneous technique by comparing results with conventional ATRs and ASSRs using click and frequency specific stimuli on 10 young adult subjects. During Phase II, the work will be expanded and a larger clinical study conducted including infants and adults of various hearing loss configurations. The device is expected to have immediate commercialization potential as an add-on software module for the thousands of current IHS users and new potential users as well.