Neuromodulation in the olfactory system

描述（由申请人提供）：值得注意的是，嗅球的颗粒细胞（GCs）在整个生命过程中不断产生，为大脑中抑制性神经元的发育和成人神经发生的研究提供了一个很好的神经元模型。与发育过程中生成的GCs一样，成年嗅球中生成的细胞必须与现有的神经元成分（包括去甲肾上腺素能系统的纤维）建立功能性连接。该系统在球茎的感觉信息处理中起着重要作用。本研究旨在了解去甲肾上腺素能系统调节嗅球GC功能的生理作用和细胞机制。在前两个目的中，我们拟探讨去甲肾上腺素兴奋作用对主嗅球和副嗅球gc的细胞机制和生理作用。最后，我们建议在嗅觉介导行为的背景下，确定去甲肾上腺素能系统在成年GCs神经发生中的作用。

DESCRIPTION (provided by applicant): Remarkably, granule cells (GCs) of the olfactory bulb are continuously born throughout life, providing an excellent neuronal model for the study of both developmental and adult neurogenesis of inhibitory neurons in the brain. As with GCs born during development, cells born in the adult olfactory bulb must establish functional connections with existing neuronal components, including the fibers of the noradrenergic system. This system plays an essential role in sensory information processing in the bulb. The aims outlined in this application seek to understand the physiological role and cellular mechanisms by which the noradrenergic system modulates GC function in the olfactory bulb. In the first two aims, we propose to investigate the cellular mechanisms and physiological role of the excitatory action of noradrenaline on GCs in the main and accessory olfactory bulb. In the last aim, we propose to determine the role of the noradrenergic system on adult neurogenesis of GCs in the context of olfactory mediated behaviors.