Mutant Mouse Aging Colony

许多NIA资助的研究使用啮齿动物来模拟衰老过程和与年龄相关的疾病。严格控制基因纯度、动物健康（包括特定病原体无状态）和环境变量是提供有效的动物模型的必要条件，这些模型可用于研究衰老的生物和行为过程。转基因、基因敲除和突变小鼠在解决正常衰老和年龄相关疾病病因学的特定问题或方面的研究中发挥了重要作用。在实验室之间共享基因工程和自然发生的突变小鼠模型大大增加了研究机会和新信息的产生。

Many NIA funded investigations use rodents to model aging processes and age-related diseases. Strict control of genetic purity, health ofthe animals including specific-pathogen-free status, and environmental variables is required to provide valid animal models that may be used to study the biological and behavioral processes in aging. Transgenic, knockout and mutant mice have added significantly to studies addressing specific questions or aspects of normal aging and age-related disease etiology. Sharing of genetically engineered and naturally occurring mutant mouse models between labs greatly enhances the research opportunities and generation of new information.