Anatomical and functional modularity of the cerebral cortex

描述（由申请人提供）：R13机制将用于支持一个科学会议，“大脑皮层的解剖和功能模块化”，重点关注最近从模块化角度描述大脑皮层组织的研究，以及这些研究如何为临床实践提供转化视角。这次会议将提供一个关于最新解剖学和生理学方法的论坛，以了解皮层模块性的基本组成部分及其在不同病理状态（如自闭症、阅读障碍和多动症）中的作用。例如，它将传播最近关于使用小柱作为中风/神经退行性疾病病例的神经修复剂的工作，以及小柱不同层之间的神经放电时间如何提供更高的认知功能。研讨会旨在鼓励在皮层模块化这一统一主题下的广泛主题的交流和深入讨论。会议所涵盖的主题将涵盖广泛的分辨率，即从小柱及其分成不同组件（例如，apica树突束）一直到大柱和相同的网络。研讨会分四次举行：1)解剖学和发育（包括胚胎学和新皮层模块的解剖划分），2)人类学（通过增加额外的小柱来解决脑化如何进行），3)计算机建模和电生理学（强调小柱并行处理的能力以及神经连接的经验模型如何帮助解释模块的涌现特性），4)病理学（讨论涉及小柱异常的几种情况）。

DESCRIPTION (provided by applicant): The R13 mechanism would be used to support a scientific conference, "Anatomical and functional modularity of the cerebral cortex", focusing on recent studies describing the organization of the cerebral cortex from a modular perspective, and how the same provides for translational perspectives into clinical practice. The conference would provide a cohesive forum on the latest anatomical and physiological approaches to understanding the basic components of cortical modularity and their involvement in different pathological states, e.g., autism, dyslexia, and ADHD. It will disseminate, for example, recent work regarding the use of minicolumns as neural prosthetics agents for cases of stroke/neurodegenerative disorders and how timing in neural firing between different layers of a minicolumn may provide for higher cognitive functions. The symposium seeks to encourage communication and in-depth discussion of a broad range of subjects under the unifying theme of cortical modularity. The topics covered at the conference would span a wide spectrum of resolution, that is, from minicolumns and their parcellation into different components (e.g., apica dendritic bundles) all the way to macrocolumns and networks of the same. The sessions of the symposium span four major areas: 1) Anatomy and Development (encompassing both embryology and anatomical compartmentalization of neocortical modules), 2) Anthropology (addressing how encephalization has proceeded through the addition of supernumerary minicolumns), 3) Computer modeling and electrophysiology (emphasizing the minicolumn's prowess for parallel processing and how empirical models of neural connectivity help explain the emergent properties of modules), and 4) Pathology (a discussion of several conditions where abnormalities of minicolumns have been implicated).