Reduced Interneuronal Space in Schizophrenic Brains

描述：（由申请人提供）据推测， 精神分裂症患者的皮质具有比对照少的神经元间空间， 特别是在第9区和第46区。这被认为反映了一种变化， 根据Selemon等人（1995）的说法，这些区域的神经元回路是一种 可能是精神分裂症的病理组成部分。这项研究，以及那些 基于神经元密度的测量。我们的目标是 两方面：一是基于皮质微柱检查这一发现， 其次，阐明神经元间隙的分布， 细胞柱的形态。我们的初步研究使用了一个小的 正常对照组（n = 16）和精神分裂症患者组（n = 9）， 根据DSM ffl-R标准诊断。我们的测试显示， 精神分裂症患者大脑9区的所有间距和神经元间距。的 最大的减少发生在微柱隔室中，其中大部分 顶端树突束、丘脑皮质和皮质-皮质纤维 本研究将检查40名精神分裂症患者（DSM IV）的柱状差异 诊断）和52个来自Runwell ifi集合的对照。标本 将从区域9、46、17和4（Brodmann）导出。磁共振图像（100倍） 将通过强大的分析仪分析第III-VI层中的Nissi染色细胞柱 计算机成像硬件和软件使研究人员能够精确地 量化细胞柱形态的细节。立体技术将是 用于估计神经元密度。如果我们的初步调查结果 经证实，比正常小的微柱将显示出 大脑回路的重组很可能是在发育过程中定义的。

DESCRIPTION: (provided by applicant) It has been postulated that the prefrontal cortices of schizophrenic patients have less interneuronal space than controls, specifically in areas 9 and 46. This is thought to reflect an alteration in the neuronal circuitry of these areas that according to Selemon et al. (1995) is a possible component of the pathology of schizophrenia. This study, and those that followed, were based on measures of neuronal density. Our goal is two-fold: one is to examine this finding based on the cortical minicolumn, and secondly, to elucidate the distribution of interneuronal space in regards to the morphology of the cell column. Our preliminary study used a small population of normal controls (n = 16) and schizophrenic patients (n = 9), diagnosed according to DSM ffl-R criteria. Our test revealed smaller values for all spacing distances and neuropil space in area 9 of schizophrenic brains. The greatest reduction occurred in the minicolumn compartment where the majority of apical dendrite bundles, thalamocortical, and cortico-cortical fibers are found. This study will examine columnar differences in 40 schizophrenic (DSM IV diagnosis) and 52 controls derived from the Runwell ifi collection. Specimens will be derived from areas 9, 46, 17, and 4 (Brodmann). Magnified images (lOOx) of Nissi-stained cell columns in layers III-VI will be analyzed by powerful computer imaging hardware and software enabling researchers to precisely quantify details of cell column morphology. Stereological techniques will be used to estimate neuronal density. If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development.