RANDOMIZED INTERVENTION FOR CHILDREN WITH VESICOURETERAL REFLUX (RIVUR)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 RIVUR研究是一项随机、双盲、安慰剂对照、多中心研究，将入组发热/症状性尿路感染（F/S UTI）和膀胱输尿管反流（VUR）儿童。 参与者随机接受安慰剂或研究药物（即磺胺甲恶唑-甲氧苄啶，标准UTI预防性抗生素），并监测2年以评估肾瘢痕形成和复发性UTI的发展。 本临床研究由CNMC泌尿科进行，要求CNMC儿科GCRC提供血液和尿液标本采集、处理和包装服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The RIVUR study is a randomized, double-blind, placebo-controlled, multi-center study that will enroll children with febrile/symptomatic urinary tract infection (F/S UTI) and vesicoureteral reflux (VUR). Participants are randomized to receive placebo or study drug (i.e. Sulfamethoxazole-Trimethoprim, the standard UTI prophylactic antibiotic), and are monitored for a 2 year period to evaluate the development of renal scarring and recurrent UTIs. Blood and urine specimen collection, processing, and packaging services were requested from the CNMC Pediatric GCRC for this clinical research study being conducted by the CNMC Division of Urology.