Mid-Atlantic Nutrition Obesity Research Center

 描述(由申请人提供)：超过三分之一的美国成年人和17%的儿童患有肥胖症，NIH已将预防和治疗肥胖症以及打破肥胖症与其相关健康状况之间的联系的研究确定为主要优先事项。大西洋中部营养和肥胖研究中心(NORC)的使命是促进多学科研究方法，以了解营养和肥胖对慢性病风险的影响，并将这些知识转化为有效的临床治疗和预防工作。为了执行这一使命，大西洋中部NORC包括一个充满活力的社区，来自三个不同机构的营养和肥胖研究人员。NORC由四个核心和两个项目组成，它们相互密切互动，无缝地向大西洋中部的NORC调查人员提供广泛的跨学科、高性价比的服务和资源。大西洋中部NORC促进了三个相互关联的研究方向：发现研究，以进行新颖的科学观察，以促进我们对疾病的正常生理学和病理生理学的理解；机制研究，以阐明有助于在健康个体中观察到的正常生理学以及肥胖症、2型糖尿病、血脂异常和非酒精性脂肪性肝病等疾病状态的病理生理学的分子、细胞和生理机制；以及临床和翻译研究，以将科学见解转化为更好的患者护理。这些研究主题得到了三个高度互动的研究核心的支持：分子遗传学和营养基因组学(MGN)、基本机制和功能基因组学(BMFG)以及临床和翻译研究(CTR)。总的来说，这些中心建立了涵盖基因组学、分子和细胞生物学、动物模型、生物统计学和计算生物学、生理学、临床和转化研究以及流行病学和人口科学的多学科研究，以推进个性化遗传和生活方式干预计划。

 DESCRIPTION (provided by applicant): Over 1/3 of adult Americans and 17% of children are obese, and NIH has identified research into preventing and treating obesity and toward breaking the link between obesity and its associated health conditions as major priorities. The mission of the Mid-Atlantic Nutrition and Obesity Research Center (NORC), now in its ninth year, is to foster multidisciplinary research approaches to understand the impact of nutrition and obesity on risk for chronic disease and translate this knowledge into effective clinical treatments and prevention efforts. Carrying out this mission, the Mid-Atlantic NORC includes a vibrant community of nutrition and obesity researchers across three different institutions. The NORC consists of four Cores and two Programs that interact closely with each other to seamlessly provide a wide range of interdisciplinary cost-effective services and resources to Mid-Atlantic NORC investigators. The Mid-Atlantic NORC promotes three inter-related strands of research: Discovery research to make novel scientific observations that advance our understanding of normal physiology as well pathophysiology of disease; Mechanistic research to elucidate the molecular, cellular, and physiological mechanisms that contribute to normal physiology observed in healthy individuals as well as the pathophysiology of disease states such as obesity, type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease; and Clinical and translational research to translate scientific insights into improved patient care. These research themes are supported by three highly interactive research cores: Molecular Genetics and Nutrigenomics (MGN), Basic Mechanisms and Functional Genomics (BMFG), and Clinical and Translational Research (CTR). Collectively, these cores build multi-disciplinary research across genomics, molecular and cell biology, animal models, biostatistics and computation biology, physiology, clinical and translational research, and epidemiology and population science to advance a program of personalized genetic and lifestyle interventions.