Research Training at the Confluence of Infectious and Non-Communicable Diseases in India

这项为期5年的全球传染病(GID)培训赠款提案的目标是在印度建立一个研究和培训计划，重点研究传染病(ID)和非传染性疾病(NCD)之间的相互作用。随着中产阶级的扩大、人口老龄化以及现代医疗和技术变得更容易获得，非传染性疾病，如糖尿病和慢性呼吸道疾病，在印度的流行率正在迅速上升。然而，包括结核病和急性呼吸道感染在内的艾滋病仍然是一个沉重的负担。印度也是细菌耐药性发展和传播的重要中心。艾滋病的高频率加上非传染性疾病日益沉重的负担，促使印度科学家需要在非传染性疾病相关传染病(NCDAID)方面具有专业知识的科学家。该项目将在印度卡纳塔克邦迈索尔的JSS大学(JSSU)建立，这是一个为迈索尔市和印度南部周边农村地区提供服务的医学教学中心。合作者包括同样位于迈索尔的印度公共卫生研究所(PHRII)，以及加州大学伯克利分校(UCB)和旧金山大学(UCSF)。这些机构的关键人员有正在进行的项目和合作。该培训计划将扩大参与这些合作的教师数量和项目范围，包括沿着两个特定轨道的项目：(1)现场流行病学和(2)分子流行病学。项目最初将侧重于与糖尿病和慢性呼吸道疾病相关的传染病。现场流行病学专业的硕士、医学或博士生(每年1-2名)将在美国接受为期6个月的培训，然后返回印度，在PHRII及其JSSU导师的支持下进行现场工作。博士生将返回美国最多12个月，与他们的美国导师一起进行高级数据分析。我们还建议在JSSU建立一个数据监测和分析/管理系统，作为研究南印度NCDAID的长期培训地点。分子流行病学课程将包括在美国对一名初级教员进行为期两年的培训，然后他将返回JSSU建立分子流行病学实验室。然后，每年一名博士生将在美国接受为期12个月的培训，然后他们将返回JSSU，在新的JSSU设施中帮助建立和完成他们的研究。每年将为分子流行病学、数据管理和分析以及指导方面的受训者和教职员工举办国内讲习班。因此，我们计划在JSSU建立长期的分子和现场流行病学研究能力，以解决由于非传染性疾病在印度日益流行而产生的新出现的ID公共卫生问题。

The goal of this 5-year Global Infectious Diseases (GID) training grant proposal is to establish a research and training program in India focused on the study of the interaction of infectious diseases (IDs) with non-communicable diseases (NCD). NCDs, such as diabetes and chronic respiratory illnesses, are rapidly increasing in prevalence in India as the middle class expands, the population ages, and modern medical care and technology become more accessible. However, IDs, including TB and acute respiratory infections, remain a substantial burden. India is also an important center for the development and spread of bacterial resistance. The high frequency of IDs combined with the substantial and growing burden of NCDs drives a need for Indian scientists with an expertise in NCD-associated infectious diseases (NCDAID). This program will be established at JSS University (JSSU), a medical teaching center in Mysore, Karnataka, India, that serves Mysore city and surrounding rural regions of South India. Collaborators include the Public Health Research Institute, India (PHRII), also located in Mysore, and the University of California at Berkeley (UCB) and San Francisco (UCSF). Key personnel at these institutions have ongoing projects and collaborations. This training program will expand the number of faculty and range of projects involved in these collaborations to include projects along two specific tracks: (1) field epidemiology and (2) molecular epidemiology. Projects will initially focus on infectious diseases associated with diabetes mellitus and chronic respiratory illnesses. Masters, medical, or doctoral candidate trainees in the field epidemiology track (1-2 per year) will train in the US for 6 months before returning to India to conduct their field work with support from PHRII and their JSSU mentors. Doctoral trainees will return to the US for up to 12 months to conduct advanced data analyses with their US mentors. We also propose to create a data surveillance and analysis/management system at JSSU that can serve as a long-term training site to study NCDAID in South India. The molecular epidemiology track will include the training of a junior faculty member in the US for 2 years, who will then return to establish a molecular epidemiology laboratory at JSSU. Then, each year a doctoral candidate will be trained for 12 months in the US who will then return to help establish and complete their research in the new JSSU facility. In-country workshops will be held annually for trainees and faculty in molecular epidemiology, data management and analysis, and mentorship. We thus plan to establish a long- term molecular and field epidemiological research capacity at JSSU that can address this emerging ID public health problem resulting from the increasing prevalence of NCDs in India.