CORE--Neuropathology/Histochemistry

本提案旨在建立埃默里神经科学研究所核心设施。埃默里大学的神经科学研究发展迅速，近年来有数十名新的研究人员接受了nind的资助。该研究以10多个基础科学和临床部门为基础，研究范围从神经功能的细胞和分子基础和神经疾病的机制，到中风和其他常见疾病的新疗法的临床试验。埃默里神经科学研究中心核心设施将为37名nind资助的研究人员和他们的51名合格资助人员协调核心活动，为这些研究人员和其他神经科学家提供各种最先进的技术和方法，以加强合作，多学科研究。该设施将利用机构对人员、设备、空间和新神经退行性疾病中心的慷慨支持，开发或扩展以下共享核心设施：a)蛋白质组学b)成像c)神经病理学/组织化学d)病毒载体和e)基因组学。作为董事，博士。Allan Levey和Ray Dingledine将通过以下方式为中心提供出色的行政支持：a)促进、协调和监测对核心的访问；B)协助预算、报告和维持财政责任；c)提供一个环境，促进利用尖端技术和多学科方法进行合作研究。由中心主任和各核心领导组成的指导委员会将至少每6个月举行一次会议，以确保公平准入，监督核心的运作，并确定优先事项和解决问题。神经系统疾病是发病和死亡的主要原因。本应用程序中描述的核心将促进广泛的nind资助的研究，旨在提高对疾病的理解，并产生新的诊断方法，治疗和预防。

This proposal seeks to establish the Emory Neuroscience NINDS Core Facilities. Neuroscience research has grown dramatically at Emory, with dozens of new investigators receiving NINDS-funding in recent years. The research, based in more than 10 basic science and clinical departments, pursues key issues ranging from the cellular and molecular basis of neural function and mechanisms of neurological disease, to clinical trials of new therapies in stroke and other common diseases. The Emory Neuroscience NINDS Core Facilities will coordinate core activities for 37 NINDS-funded investigators and their 51 qualifying grants, to provide these investigators and other neuroscientists access to a variety of state-of-the-art technologies and approaches that will enhance collaborative, multidisciplinary research. The facility will leverage generous institutional support for personnel, equipment, space and the new Center for Neurodegenerative Disease, to develop or expand the following shared core facilities: a) Proteomics b) Imaging c) Neuropathology/Histochemistry d) Viral Vector and e) Genomics. As directors, Drs. Allan Levey and Ray Dingledine will provide outstanding administrative support for the Center by a) facilitating, coordinating and monitoring access to the cores; b) assisting with budgeting, reporting, and maintaining fiscal responsibility; and c) providing an environment that fosters collaborative research utilizing cutting edge technologies and multidisciplinary approaches. A steering committee comprised of the Directors of the Center and the leaders of the respective Cores will meet at least once every 6 months to assure fair access, provide oversight of the operations of the cores, and to establish priorities and resolves issues. Neurological disorders are major causes of morbidity and mortality. The cores described in this application will facilitate a broad range of NINDS-sponsored research at Emory that is aimed at improving the understanding of disease, and producing new diagnostic approaches, therapies, and prevention.