Advancing Physiological Signal Analysis for Mind-Body Research

描述(由申请者提供)：这个职业发展中期奖将为Oken博士提供有保障的时间来指导和提高他在生理信号采集和分析方面的能力。虽然他已经是一位成功的导师，但他的导师成为成功的NIH资助的院士就证明了这一点，但他执导的T32项目缺乏任何工资支持，这已经并将进一步限制他的时间。本次成功的T32目前已有博士后5名，博士后1名。这位博士前候选人是T32考试的第一名，她已经宣布Oken博士是她的行为神经科学博士论文的主要导师。除了增加目前的导师角色，K24还将允许Oken博士为他指导的T32课程制定正式课程，为非CAM临床研究和基础科学实习生提供与CAM相关的讲座，并将时间分配给OHSU副院长正在制定的导师和职业发展计划。除了足够的资金来更好地指导其他人，奥肯博士还将把这项职业发展奖的很大一部分资金用于提升他的实验室的信号分析和采集能力，包括加强对与个人数字助理接口的24小时录音设备的使用。这一开发将利用Mikel Aickin博士、Deniz Erdgomus博士和罗杰·埃林森(MSEE)的技术支持。这些系统将提供给T32上的那些人和其他对这些技术感兴趣的初级教员。其中一些职业发展基金将允许奥肯博士在波特兰州立大学攻读研究生级别的系统科学课程。这些分析技术将有助于以下方面的发展：冥想干预的依从性和质量的生理学测量；基于信息论的电极间脑电相关性测量，其可能比该领域其他人已经使用的参数同步测量更有效；以及24小时心率变异性的应激敏感测量。与24小时记录设备连接的个人数字助理允许频繁、基于经验地对与心身相关的自我评估指标进行采样，例如在实验室外受试者通常环境中的感知压力和专注力。这些测量将与使用系统科学方法的生理测量相关。 公共卫生相关性：这项应用的总体目标是促进Oken博士更好地指导临床补充医学研究人员的能力，并推动心身研究领域的发展。要做到这一点，奥肯博士将减少一些行政和临床责任，并开发可用于心身研究的新的生理指标，包括测量压力、坚持干预措施以及对大脑的积极影响。从实践的角度来看，这一应用将导致更多合格的年轻CAM临床研究人员，并改善心身医学的临床试验。更好地理解心身医学的益处，甚至可能改进心身技术本身，对几乎所有的医疗保健和健康促进都有广泛的健康影响。

DESCRIPTION (provided by applicant): This mid-career development award will provide protected time for Dr. Oken to mentor and to advance his capability in physiological signal acquisition and analysis. While already a successful mentor, as evidenced by his mentees becoming successful NIH-funded academicians, his time has been and will be further limited by the lack of any salary support for the T32 he directs. This successful T32 currently has 5 post-doctoral and one pre-doctoral candidate. The pre-doctoral candidate is the first on the T32 and she has declared Dr Oken to be her primary mentor for her Behavioral Neuroscience PhD thesis. In addition to increasing current mentorship roles, the K24 will allow Dr. Oken to develop a formal curricula for the T32 he directs, give CAM-related lectures to non-CAM clinical research and basic science trainees, and to allocate time to the mentorship and career development program that the OHSU associate dean is developing. Besides sufficient funding to better mentor others, Dr. Oken will also spend a significant portion of this career development award advancing his lab's capability for signal analysis and acquisition including the enhanced use of a 24-hour recording device that is interfaced with a personal digital assistant. This development will utilize the technical support of Mikel Aickin, PhD, Deniz Erdgomus, PhD, and Roger Ellingson, MSEE. These systems will be available to those on the T32 and other junior faculty interested in these techniques. Some of the career development funds will allow Dr. Oken to take graduate level Systems Science courses at Portland State University. The analysis techniques will aid development of: a physiologic measure of adherence to and quality of meditation interventions; a measure of interelectrode EEG correlation based on information theory that is likely more valid than parametric synchrony measures already used by others in the field; and a stress- sensitive measure of 24-hour heart rate variability. The personal digital assistant interfaced to the 24-hour recording device allows for frequent, experience-based sampling of self-rated measures relevant to mind-body such as perceived stress and mindfulness outside the laboratory in the subject's usual environment. These measurements will be related to the physiological measurements using systems science approaches. PUBLIC HEALTH RELEVANCE: The general goal of this application is to promote Dr. Oken's ability to better mentor clinical complementary medicine researchers and to advance the field of mind-body research. This will be done by allowing Dr. Oken to decrease some of his administrative and clinical responsibilities and by developing new physiologic measures that can be used in mind-body research, including measures of stress, adherence to interventions, and positive effects on the brain. From a practical perspective this application will lead to more qualified young CAM clinical researchers and to improved clinical trials of mind-body medicine. Improved understanding of the benefits of mind-body medicine and possibly even improving mind-body techniques themselves has broad health implications to almost all medical care and health promotion.