MORPHOLOGY CORE

形态学分析仍然是可视化不同细胞空间关系的重要工具 类型，并研究胃肠道中的细胞成分。该形态学核心设施的独特之处在于 它为参与研究者提供的关于胃肠道结构生物学的专业知识。其主要 其功能是培训和协助研究人员进行胃肠道的形态学分析。 作为快速处理组织标本的重要资源，并为研究人员提供 用于标记组织切片的新开发的方法/方案和试剂。在此之前， 核心，DDRCC研究者获得组织学服务的机会很少（可用性有限，周转时间长， 质量不一，收费高）。由于许多DDRCC调查人员都是资源有限的初级教员， 对形态学核心的资助和使用使这一群体以及更高级的研究人员受益 (see Exhibit）。该中心提供与胃肠道组织和细胞加工相关的专业技术服务 样品这些功能需要在昂贵的设备、样品制备和操作方面进行投资 精密仪器的生产需要训练有素的经验丰富的技术人员。因此， 将仪器和高技能技术支持集中在集中管理的设施中，具有成本效益 在那里它们可以被利用很高的时间百分比。DDRCC形态学核心是唯一的组织学 该机构提供免疫组织化学染色，按服务收费。的 形态学核心也是该机构集体专业知识的焦点， 新技术它促进了抗体和组织块等试剂的交换，并促进了 DDRCC成员之间的许多合作。

Morphologic analysis remains an essential tool for visualizing the spatial relationships of different cell types, and studying cellular components in the Gl tract. The unique feature of this Morphology Core Facility is the expertise it provides to participating investigators on the structural biology of the Gl tract. Its primary function has been to train and assist investigators in the morphologic analysis of the Gl tract It has also served as an important resource for rapid processing of tissue specimens and for providing investigators with newly developed methods/protocols and reagents for labeling tissue sections. Before the establishment of this Core, DDRCC investigators had poor access to histology services (limited availability, long turn-around, variable quality, and high fees). Because many DDRCC investigators are junior faculty with limited resources, funding for, and access to, the Morphology core has benefited this group, as well as more senior investigators (see Exhibit). This core has provides expert technical service related to the processing of Gl tissue and cell samples. These functions require investment in expensive equipment, and sample preparation and operation of sophisticated instrumentation require highly trained experienced technicians. It is, therefore, much more cost effective to concentrate instrumentation and highly skilled technical support in a centrally managed facility where they can be utilized a high percentage ofthe time. The DDRCC Morphology Core is the onlv histology facilitv at this institution that provides immunohistochemical staining on a fee for service basis. The Morphology Core also serves as a focus for the collective expertise at this institution and rapid dissemination of new techniques. It facilitates exchange of reagents such as antibodies and tissue blocks, and has fostered many collaborations between DDRCC members.