Comparative Effectiveness of Interventions for Depression in the Community

项目总结 这项独立研究科学家奖申请的目标是保护必要的时间，以进一步 培养我作为一名新的独立研究人员的技能，专门研究干预措施的比较有效性 社区精神卫生系统中的抑郁症患者。这个奖项会让我成为一个老练的人 使用最先进的方法和统计方法的比较有效性研究人员 研究干预措施对缓解高度公共卫生优先的精神卫生障碍的效果。我的 研究计划和计划的职业发展活动是基于比较的定义 由医学研究所的比较有效性委员会详细阐述的有效性研究 确定研究的优先顺序。我的目标是与专家顾问合作，参加培训活动，采取 我的比较有效性研究项目更上一层楼。为了补充我目前的计划 社区精神卫生系统抑郁症干预效果评价研究 在人群层面为临床决策提供信息，我的目标是发展方法和 统计方法，使我的研究能够解决如何有效地 传播有效的干预措施，以满足抑郁症服务消费者的个人需求。这 获奖将为我提供参与最新统计数据课堂教学所需的时间 方法，参加培训研讨会和研究所，与专家顾问合作，并参加会议以 加强我作为比较有效性研究人员的发展。这一奖项还将使我获得 需要时间、专家咨询和教育来进行两项重要的研究，以告知高效的 抑郁症干预措施在社区的传播：一项关于患者基线调节因素的研究 治疗效果及与精神卫生服务利用相关的医疗服务利用和费用研究 社区精神卫生系统中对MDD的健康干预。这次调查的具体目的是 包括1)评估患者基线技能缺陷是否影响动态治疗的有效性 社区精神卫生环境下重度抑郁症患者的认知治疗2) 评估患者基线缺陷是否影响动态治疗和认知治疗的有效性 对结果的二级测量进行治疗，3)探索其他基线患者变量，这些变量可能 这些心理治疗方法对重度抑郁障碍患者的适度疗效 在社区精神卫生环境中接受治疗，以及4)评估医疗保健利用率和相关成本 在社区精神卫生系统中接受抑郁症心理治疗的患者与 接受替代治疗的患者。

PROJECT SUMMARY The goal of this independent research scientist award application is to protect the time necessary to further develop my skills as a newly independent researcher specializing in comparative effectiveness of interventions for depression in the community mental health system. This award would allow me to become a sophisticated comparative effectiveness researcher utilizing state-of-the-art methodologies and statistical approaches to study the effectiveness of interventions in alleviating mental health disorders of high public health priority. My program of research and planned career development activities are based on the definition of comparative effectiveness research elaborated by the Institute for Medicine's Committee on Comparative Effectiveness Research Prioritization. It is my goal to work with expert consultants and participate in training activities to take my comparative effectiveness research program to the next level. To complement my current program of research evaluating the effectiveness of interventions for depression in the community mental health system that inform clinical decision making at the population level, my goal is to develop expertise in methods and statistical approaches that would allow my research to address the important question of how to efficiently disseminate effective interventions to meet the needs of individual consumers of services for depression. This award would afford me the time needed to participate in classroom instruction in the newest statistical approaches, attend training seminars and institutes, work with expert consultants, and attend conferences to enhance my development as a comparative effectiveness researcher. This award would also allow me the time, expert consultation, and education needed to conduct two important studies to inform the efficient dissemination of interventions for depression in the community: a study of the patient baseline moderators of treatment effectiveness and a study of healthcare utilization and costs associated with the utilization of mental health interventions for MDD in the community mental health system. The specific aims of this investigation include 1) to assess whether patient baseline skills deficits moderate the effectiveness of dynamic therapy and cognitive therapy for patients with major depressive disorder treated in the community mental health setting, 2) to assess whether patient baseline deficits moderate the effectiveness of dynamic therapy and cognitive therapy on secondary measures of outcome, 3) to explore additional baseline patient variables that may moderate the effectiveness of these psychotherapeutic approaches for patients with major depressive disorder treated in the community mental health setting, and 4) to evaluate healthcare utilization and associated costs for patients treated with psychotherapy for depression in the community mental health system compared to patients who receive alternative treatments.