课题基金 / 基金详情

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells
HIV-1 进入并转移至 CD4 T 细胞的机制
批准号：
8745628
负责人：
John Mascola
金额：
$22.07万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8745628
关键词：
Animal ModelCD4 Positive T LymphocytesCell DeathCell SurvivalCellsCessation of lifeGoalsHIV InfectionsHIV-1Helper-Inducer T-LymphocyteHumanIndividualInfectionLeadMacacaModelingMolecularResearch DesignT-Cell DepletionT-LymphocyteTestingTherapeutic InterventionViralViral ProteinsViremiaVirusVirus Diseasescell killingimmune functionimprovedviral DNA

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相关文献

中文摘要
翻译
在过去的一年里，研究的一个主要重点是继续在分子和细胞水平上更好地理解艾滋病毒-1诱导的细胞死亡，并在动物模型中测试治疗干预措施。该实验室继续进行不同因素的研究，以更好地了解艾滋病毒感染过程中T细胞的死亡。这些研究的结果旨在帮助揭示和确定特定病毒基因产物和病毒感染背景下CD4T细胞耗尽的机制。
英文摘要
A major focus of study during the past year has been to continue to better understand HIV-1 induced cell death at the molecular and cellular levels and to test therapeutic interventions in animal models. The lab continued their ongoing studies of different factors to better understand T cell death during HIV infection. The results of these studies are designed to help uncover and define the mechanisms involved in CD4 T cell depletion by specific viral gene products and in the context of viral infection.
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