FASEB SRC on TGF beta Superfamily: Signaling in Development and Disease

描述（由申请人提供）：TGF-？超家族包括大量分泌的细胞因子，其起源于进化中的有组织的多细胞生命的开始。这些细胞间信号传导蛋白调节大量的发育、生理和稳态过程。最近大量的工作已经进入了解TGF-β的分子机制？信号传导以及该信号传导途径中的异常导致发育异常和人类疾病病理的方式。本次会议有三个主要目标。第一个是提供一个场所整合生化知识的信号转导机制在分子和细胞水平，系统的方法，旨在描述这些因素如何协调发展过程，并有助于各种人类疾病状态，包括癌症，心血管和代谢紊乱和肌肉骨骼和神经系统病理。我们将通过一个多样化和互动的讲座和海报会议计划来实现这一目标，按主题组织，所有这些都在一个亲密的环境中进行，参与者人数有限。我们邀请了广泛的专家，涵盖了TGF-β的各种生物学作用的所有关键和新兴方面。家庭成员本次会议的第二个目标是帮助年轻的科学家，少数民族和妇女融入这个不断增长的领域，并激励他们为未来的创新和发现铺平道路。建立一个非正式和创造性论坛的第三个目标也是密切交织在一起的， 不断为建立国家和国际合作奠定肥沃的土壤，特别是在从事互补主题工作的专家之间，例如生物化学家与胚胎学家，干细胞生物学家与临床研究人员。这种富有成效的环境在过去，现在甚至会进一步，有助于产生更系统的方法信号网络，其生物学基础和手段，利用它们诊断和治疗的发展。我们在具有相同目标的前六次会议上积累的集体经验使我们坚信，我们的目标将得到实现，并将为传播这一成功领域铺平道路。

DESCRIPTION (provided by applicant): The TGF-? superfamily encompasses a large number of secreted cytokines that originated at the onset of organized multi-cellular life in evolution. These cell-to-cell signaling proteins regulate an extensive number of developmental, physiological and homeostatic processes. A great deal of recent work has gone into understanding the molecular mechanisms of TGF-?? signaling and the way in which aberrations in this signaling pathway lead to developmental abnormalities and human disease pathologies. There are three primary objectives of this conference. The first is to offer a venue for integratin biochemical knowledge about signal transduction mechanisms at the molecular and cellular level, with systems approaches that aim to describe how these factors coordinate developmental processes and contribute to various human disease states, including, cancer, cardiovascular and metabolic disorders and musculoskeletal and nervous system pathologies. We will accomplish this goal through a diverse and interactive program of talks and poster sessions, organized by theme, and all held in an intimate setting with a limited number of participants. We have invited a wide spectrum of specialists that cover all the key and emerging aspects of the diverse biological roles of TGF-?? family members. A second goal for this conference is to help younger scientists, minorities and women integrate to this ever-increasing field and stimulate them to lead the way for the future steps of innovation and discovery. Intimately intertwined is also the third objective of creating the informal and creative forum that continuously seeds the fertile soil for building national and international collaborations, especially between experts working on complementary themes, for example biochemists with embryologists and stem cell biologists with clinically oriented researchers. This productive environment has in the past, and will even further now, contributed to the generation of more systemic approaches to the signaling networks, their biological underpinnings and the means to exploit them diagnostically and in the development of therapy. Our collective experience that has been built over six previous conferences with the same goals provides us with the strong confidence that our objectives will be met and will pave the way to the propagation of this successful field.