Inflammatory Biology Core

项目摘要(参见说明)：加州大学洛杉矶分校和其他机构的OAIC炎症生物学核心(IBC)提供了一种机制，通过该机制，加州大学洛杉矶分校和其他机构的OAIC研究项目可以将对炎症生物学的全面蛋白质和分子分析纳入以下研究：a)确定导致脆弱成年人疾病和残疾的生物和/或行为因素；b)开发针对炎症或与炎症相关的生物行为风险特征的有效预防或治疗干预措施；c)将有关炎症生物学生物标志物的新知识和成功临床干预措施背后的机制带入临床实践和决策。IBC侧重于促进基础研究和临床研究之间的联系，并为OAIC研究项目提供机会，以研究炎症的潜在分子遗传学以及炎症对其他细胞过程的影响，战略重点是将这些知识转化为识别和减少老年人慢性病和残疾的风险。IBC的目标是在现有的加州大学洛杉矶分校OAIC研究项目以及新的OAIC试点项目和开发的研究项目中扩大和支持(智力支持和分析服务)炎症生物学分析。IBC还将开发新的分析方法，以促进体内分析炎症动力学及其对老年人的功能基因组影响。最后，IBC将提供一般炎症生物学的行为、免疫学和分子方面的培训，以及与衰老相关的独特问题。这项培训将强调有关炎症信号的来源和目标的生物学知识(包括遗传和表观遗传影响以及基因表达后果)，特别侧重于行为和功能影响。总而言之，炎症生物学核心是加州大学洛杉矶分校OAIC不可或缺的一部分，为OAIC试点项目和CDA获奖者提供炎症生物学评估的专家咨询，监督炎症生物标记物的收集和分析，解释数据，以及支持许多外部资助的项目。鉴于炎症在影响老年人的疾病中的突出作用，以及伴随着衰老而改变的炎症动力学，对炎症生物学的全面评估对于OALC的核心目标至关重要，即开发预防美国老年人疾病和残疾的干预措施，并将这些知识转化为更有效的临床实践。

PROJECT SUMMARY (See instructions): The OAIC Inflammatory Biology Core (IBC) provides a mechanism by which OAIC research programs at UCLA and other institutions can incorporate comprehensive protein and molecular analyses of inflammatory biology into studies that a) identify biologic and/or behavioral factors that contribute to disease and disability in vulnerable adults, b) develop effective preventive or therapeutic interventions that target inflammation or biobehavioral risk profiles associated with inflammation, and c) bring new knowledge about inflammatory biology biomarkers and mechanisms underlying successful clinical intervention into clinical practice and decision-making. The IBC focuses on stimulating links between basic and clinical research, and provides opportunities for OAIC research projects to examine the underlying molecular genetics of inflammation and the effects of inflammation on other cellular processes, with a strategic focus on the translation of such knowledge into the identification and reduction of risk for chronic disease and disability in older adults. The IBC aims to expand and support (both intellectual support and assay services) the analysis of inflammatory biology in existing UCLA OAIC research programs and in new OAIC pilot projects and developing research programs. The IBC will also develop new analytic approaches to facilitate in vivo analysis of inflammatory dynamics and their functional genomic impact on elderly individuals. Finally, the IBC will provide training in behavioral, immunologic, and molecular aspects of inflammatory biology in general, and as they pertain to the unique issues in aging. This training will emphasize biological knowledge about the sources and targets of inflammatory signals (including genetic and epigenetic influences and gene expression consequences), with a particular focus on behavioral and functional impacts. In summary, the Inflammatory Biology Core forms an integral part of the UCLA OAIC, providing expert consultation on the assessment of inflammatory biology, oversight of inflammatory biomarker collection and assay, and interpretation of data for OAIC pilot projects and CDA awardees as well as support for numerous externally-funded projects. Given the prominent role of inflammation in the diseases that impact older adults, and the altered inflammatory dynamics that accompany aging, comprehensive assessment of inflammatory biology is critical to OAlC's central goal to develop interventions that prevent disease and disability in older Americans, and to translate such knowledge into more effective clinical practice.