UCLA Older Americans Independence Center

描述(由申请人提供)：加州大学洛杉矶分校克劳德·佩珀老年美国人独立中心(OAIC)旨在促进旨在维护和恢复老年人独立性的研究。通过其主题为预防脆弱人群中的疾病和残疾：翻译方法，加州大学洛杉矶分校OALC的研究跨越了从T1到T2的全部翻译研究。在这一主题中，加州大学洛杉矶分校OAIC的一个重要重点是了解炎症在疾病和残疾中的作用。 为了实现其目标，加州大学洛杉矶分校OAIC建立了4个研究核心(招聘和保留、研究运作、分析和成本效益以及炎症生物学)和一个新的信息传播核心，该核心将在每个步骤(招聘、测量、数据管理、分析、解释和采用研究结果)促进与OALC相关的研究。研究核心在4个层面上提供支持： 咨询(例如，提供长达数小时的建议、阅读一篇论文或一份提案) 就新提案建立伙伴关系 短期(例如，最多2-3天的咨询、执行化验) 持续的或长期的支持(例如，持续的、项目团队的一部分) 此外，加州大学洛杉矶分校OAIC飞行员和探索性研究核心和研究职业发展核心通过初级研究人员和飞行员奖项的渠道激励新的研究，并招募成功的研究人员参与OALC相关研究。领导/行政核心确保完成这些具体活动，并以最佳方式实现加州大学洛杉矶分校OAIC的目标。 加州大学洛杉矶分校OAIC将解决弱势老年人面临的健康差距，原因有1)对健康和特定疾病(如艾滋病毒、睡眠、抑郁症)的贡献者(如社会经济地位、炎症)了解不足，2)缺乏有效的预防或治疗方法(生物医学和行为)，或3)向弱势老年人提供必要治疗的能力不足(如文化障碍、卫生保健系统效率低下)。通过OAIC集中努力和资源，可以加快研究开发、测试和传播有希望的创新以保持独立性的时间表。

DESCRIPTION (provided by applicant): The UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to promote research aimed at maintaining and restoring the independence of older persons. Through its theme of Preventing Disease and Disability in Vulnerable Populations: a Translational Approach, the UCLA OAlC's research extends across the full spectrum from Tl to T2 translational research. Within this theme, an important focus of the UCLA OAIC is on understanding the role of inflammation in disease and disability. To accomplish its goals, the UCLA OAIC has established 4 Research Cores (Recruitment and Retention, Research Operations, Analysis and Cost Effectiveness, and Inflammatory Biology) and a new Information Dissemination Core that will facilitate OAlC-related research at every step (recruitment, measurement, data management, analysis, interpretation, and adoption of findings). Research cores provide support at 4 levels: Consultation (e.g., providing up to several hours of advice, reading a paper or a proposal) Partnership on new proposals Short-term (e.g., up to 2-3 days of consultation, performing assays) Ongoing or long-term support (e.g., ongoing, part of the project team) In addition, the UCLA OAIC Pilot and Exploratory Studies Core and Research Career Development Core stimulate new research via a pipeline of junior investigators and pilot awards and recruit successful investigators into OAlC-related research. The Leadership/Administrative Core ensures that these specific activities are accomplished and the goals of the UCLA OAIC are optimally achieved. The UCLA OAIC will address health disparities that vulnerable older persons face because of 1) inadequate understanding of contributors (e.g., socioeconomic status, inflammation) to health and specific illnesses (e.g., HIV, sleep, depression), 2) lack of effective preventive or therapeutc approaches (biomedical and behavioral), or 3) inadequate ability to get needed treatment to vulnerable older populations (e.g., cultural barriers, ineffective health care systems). By focusin efforts and resources through the OAIC, the timeline for research to develop, test, and disseminate promising innovations to maintain independence can be accelerated.