Administrative Core

项目总结(见说明)： 题为“模拟宿主反应以了解严重的人类病毒感染”的项目的行政核心将向研究项目(RPI：流感和埃博拉病毒研究；RP2：西尼罗河病毒研究项目)和其他项目核心(核心A：蛋白质组学、代谢组学和类脂组学核心；核心B：计算建模核心；核心C：数据传播和资源共享核心)提供支持，并协调项目活动。该项目的总体目标是确定宿主细胞反应的特征，这些反应决定了潜在致命病毒感染的结果。作为行政核心的首席调查员和领导者，川冈义弘博士将负责整个项目并实现概述的目标。行政核心将：(1)召集实现项目提案所述目标所需的工作人员，确保专业知识和承诺与项目目标相称；(2)确定里程碑，并制定将经常审查的时间表，以保持项目的目标；(3)监督预算资源，以确保项目达到预期目标。优化产出并确保支出适当；(4)通过定期网播、面对面会议和频繁的电子邮件联系，促进项目成员和核心成员之间的良好沟通，并与国家国际开发署项目科学家和指导委员会定期互动；(5)支持数据管理和资源共享目标，管理实验室信息管理系统，确保项目内的数据共享得到优化，并通过数据公共门户网站和数据、分析、软件、模型和生物资源公共储存库迅速共享数据和资源；(6)制定培训计划，帮助其他传染病研究人员了解组学方法；(7)建立试点研究计划，为与该项目相关的短期创新项目提供资金。

PROJECT SUMMARY (See instructions): The Administrative Core for the project entitled "Modeling Host Responses to Understand Severe Human Virus Infections" will provide support to the Research projects (RPI: Influenza and Ebola virus research; RP2: West Nile virus research project) and the other project cores (Core A: Proteomics, Metabolomics and Lipidomics Core; Core B: Computational Modeling Core; Core C: Data Dissemination and Resource Sharing Core) and coordinate project activities. The overall objective of the project is to characterize host cell responses that determine the outcome of potentially lethal viral infections. As Principal Investigator and Leader of the Administrative Core, Dr. Yoshihiro Kawaoka will be responsible for the overall project and for meeting the objectives outlined. The Administrative Core will (1) assemble the staff needed to meet the objectives outlined in the project proposal, ensuring the expertise and commitment is commensurate with project goals; (2) identify milestones and establish timelines which will be reviewed frequently to keep the project on target; (3) oversee budget resources to. optimize outputs and ensure spending is appropriate; (4) foster good communications among members of the projects and cores via regular webcasts, in-person meetings and frequent email contact, and provide regular interaction with the NIAID Project Scientist and the Steering Committee; (5) support the data management and resource sharing objectives, curate the Laboratory Information Management System (LIMS), ensure data sharing within the project is optimized, and that data and resources are shared promptly via a public web portal for data and public repositories for data, analyses, software, models and biological resources; (6) develop a Training Program to help other infectious disease researchers learn about OMICs approaches and (7) establish a Pilot Research Program to fund short-term innovative projects relevant to the project.