2013 Antimicrobial Peptides GRC/GRS

描述（由申请人提供）：第九届戈登研究会议（GRC）抗菌肽（AMPs）将于2月24日至3月1日在加利福尼亚州文图拉举行。AMP是所有后生动物（包括细菌、真菌、植物、无脊椎动物、脊椎动物和哺乳动物，包括人）使用的先天免疫的内源性组分。它们作为天然抗生素，通过阻止入侵和杀死病原体，并限制非病原微生物的生长。抗生素耐药微生物的出现强调了研究抗菌肽的必要性。此外，其他证据表明，AMP在各种生物环境中介导宿主防御，并且可以以不同于其抗微生物功能的方式起作用， 通过受体介导的炎症相关活性如趋化性或诱导细胞因子产生，支持AMP是多功能宿主防御效应分子的假设。最近的证据表明微生物和宿主来源的AMP在维持调节肠道微生物群的组成和保护宿主免受感染中的作用。了解AMP在免疫应答中的作用将有助于改善对人类疾病病理生理学的理解和治疗，包括炎症性肠病、性传播和机会性感染、特应性皮炎等。该计划将分为9个会议的口头报告和四个海报会议。会议由Nita Salzman博士和Gill Diamond博士以及联合副主席Julia Dorin博士和Pieter Hiemstra博士共同主持，并将由Jules Hoffmann教授发表主旨演讲。将特别注意包括初级教师和学生的参与者。发言者将包括那些根据最近的重要发现提前选择的人，以及那些从提交的摘要中选择的人。会议主题将包括：抗菌宿主防御的保护;抗菌肽作为抗病毒药物;宿主防御真菌和寄生虫;环抗菌肽;抗菌肽在界面;抗菌和超越;抗菌肽和免疫;以及抗菌肽的新技术和应用。与会者有充分的时间进行有组织的讨论和非正式互动。此外，每天的会议，包括“热点和最新消息”将专门讨论当前调查的前沿话题。组织理念是鼓励多样化的参与，并关注性别问题、青年科学家、少数民族和身体有缺陷的个人。

DESCRIPTION (provided by applicant): The 9th Gordon Research Conference (GRC) on Antimicrobial Peptides (AMPs) will meet in Ventura, CA, from February 24-March 1. AMPs are endogenous components of innate immunity used by all metazoans including bacteria, fungi, plants, invertebrates, vertebrates, and mammals including humans. They act as natural antibiotics by prohibiting invasion and killing pathogens, and by restricting growth of non-pathogenic microbes. The emergence of antibiotic-resistant microorganisms underscores the need to study AMPs. Furthermore, additional evidence shows that AMPs mediate host defense in a variety of biological settings and can act in ways distinct from their antimicrobial function, via receptor-mediated inflammation- associated activities such as chemotaxis or induction of cytokine production, supporting the hypothesis that AMPs are multifunctional host defense effector molecules. Recent evidence indicates a role of microbe- and host-derived AMPs in maintaining regulating the composition of the commensal microbiota and protection of the host from infection. Knowledge of the roles of AMPs in immune responses will contribute to improved understanding and treatment of the pathophysiology of human diseases, including inflammatory bowel disease, sexually transmitted and opportunistic infections, atopic dermatitis, and others. The program will be divided into 9 sessions of oral presentations and four poster sessions. The conference is co-chaired by Drs. Nita Salzman and Gill Diamond, together with the co-vice-chairs, Drs. Julia Dorin and Pieter Hiemstra, and will open with a keynote address presented by Professor Jules Hoffmann. Special attention will be made to include junior faculty and student participants. Speakers will include those selected in advance based on recent important discoveries, and those selected from submitted abstracts. Session topics will include: Conservation of Antibacterial Host Defense; AMPs as Antivirals; Host Defense against Fungi and Parasites; Cyclic AMPs; AMPs at the Interface; Antimicrobial and Beyond; AMPs and Immunity; and Novel Technologies and Applications for AMPs. Ample time for organized discussion and informal interactions between participants has been included. In addition, daily sessions, including "Hot Corner and Late Breaking News" will be devoted to discussing topics at the cutting edge of current investigation. The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with physical limitations.