2013 Cellular and Molecular Mechanisms of Toxicity Gordon Research Conference and

描述(申请人提供)：基础分子毒理学继续支持环境、制药和工业科学的关键创新。全球对药品和环境暴露的监管以及公众对风险的看法正在发生很大变化。为了迎接这些挑战，这一领域的发展科学需要保持在法规、政治和立法的领先地位。因此，这次会议将展示支持环境、制药和工业科学关键创新的尖端机械毒理学研究，并预示着在寻求预测和规避药物和毒物不良反应方面的一个激动人心的时期。会议将讨论广泛的主题，如线粒体疾病、表观遗传学、纳米技术、药物代谢酶的转录控制、癌症发生、干细胞在毒理学研究中的作用以及与氧化应激相关的转录因子的新功能。会议将汇集一批处于各自领域前沿的研究人员，并将为初级科学家、研究生和本科生提供机会，以海报形式介绍他们的工作，并与该领域的领导人交流意见。一些海报主持人将被挑选出来进行简短的演讲。这次会议气氛热烈，有计划的讨论会议以及在下午和晚上举行非正式聚会的机会，为来自不同学科的科学家提供了集思广益的途径，并促进了所代表的不同研究领域的跨学科合作。今年的一个新组成部分是与本次会议同时举行的戈登研究研讨会(GRS)。这是一个独特的论坛，供研究生、博士后和其他具有类似经验和教育水平的科学家建立网络，展示和交流新数据和前沿思想。

DESCRIPTION (provided by applicant): Basic molecular toxicology continues to underpin key innovations in environmental, pharmaceutical and industrial sciences. Much is changing in global regulation of pharmaceutical and environmental exposures and also in public perception of risk. In order to meet these challenges, the developing science in this area needs to keep ahead of regulation, politics and legislation. Thus, this conference will present cutting edge mechanistic toxicological research underpinning key innovations in environmental, pharmaceutical and industrial sciences and heralds an exciting period in the quest to predict and circumvent adverse drug and toxicant reactions. The Conference will feature a wide range of topics, such as mitochondrial diseases, epigenetics, nanotechnology, transcriptional control of drug metabolizing enzymes, carcinogenesis, stem cells in toxicological research and novel functions of oxidative stress-related transcription factors. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunitiesfor junior scientists, graduate and undergraduate students to present their work in poster format and exchange ideas with leaders in the field. A number of poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. A new component this year is the Gordon Research Seminar (GRS) held in conjunction with this conference. This is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to network and present and exchange new data and cutting edge ideas.