Health behaviors over the adult lifecourse and cognitive aging

项目总结 成人生命周期的健康行为与认知老化 越来越多的证据表明，健康行为和认知老化之间存在关联。吸烟， 酒精、体力活动和营养都被发现与认知功能低下和 痴呆症。健康行为能够解释认知老化轨迹的程度是相当公开的 与健康相关，特别是因为它们可能是痴呆症的关键可改变的风险因素。最重要的是 这项建议的目的是检查健康行为对成年人生活过程的综合影响 确定从中年开始的认知老化轨迹。具体目标是： 1.研究吸烟、饮酒、体力活动和饮食对认知的综合影响 为了评估健康行为对中年早期、中期和晚期的影响是否最大 重要，以及这种影响是否随着时间的推移而积累。 2.检查一种行为的变化在多大程度上导致其他行为的变化，以及在多大程度上 这些变化会影响认知老化。 3.考察从中年开始的健康行为和认知老化之间的双向关联： 4.检查生物变化的程度，如血管危险因素和疾病的变化， 解释健康行为和认知老化之间的联系。我们还将审查所扮演的角色 健康行为和认知老化之间关系的两个潜在效应修饰物： 社会经济地位(SES)和载脂蛋白E(APOE)e4等位基因。 此外，我们的工作将集中在健康行为测量的问题上：将给予详细的关注 对健康行为的分类，以了解每个健康行为之间的联系的形状 行为和认知老化的衡量标准，不同的饮食衡量标准是否与 认知老化与主观测量和客观测量之间是否存在差异 体力活动。我们还将研究健康行为对认知老化特定领域的影响， 记忆和执行功能是两个主要方面。 白厅II测试电池在阶段5被引入到整个白厅II队列中，当时参与者 平均年龄55岁，在过去10年里已经接受过行为评估。第三波 认知数据目前正在收集中，将于2009年底提供，使我们能够看到 认知变化。尽管该提案主要基于英国白厅，但研究团队 由法国和英国的科学家组成，为我们提供了验证一些 我们的结果来自法国GAZEL研究的数据。

PROJECT SUMMARY Health behaviors over the adult lifecourse and cognitive aging There is increasing evidence of an association between health behaviors and cognitive aging. Smoking, alcohol, physical activity and nutrition have all been found to be associated with poor cognitive function and dementia. The extent to which health behaviors can explain cognitive aging trajectories is of substantial public health relevance, particularly as they may be 'the' key modifiable risk factors for dementia. The overarching aim of this proposal is to examine the combined impact of health behaviors over the adult lifecourse in determining cognitive aging trajectories starting from midlife. The specific aims are: 1. To examine the combined impact of smoking, alcohol consumption, physical activity and diet on cognitive decline in order to assess whether the impact of health behaviors in early, mid and late midlife is most important and whether this effect accumulates over time. 2. To examine the extent to which change in one behavior leads to changes in others and the extent to which these changes influence cognitive aging. 3. To examine bidirectional associations between health behaviors and cognitive aging starting in midlife: 4. To examine the extent to which biological changes, such as those in vascular risk factors and diseases, explain the association between health behaviors and cognitive aging. We will also examine the role played by two potential effect modifiers of the association between health behaviors and cognitive aging: socioeconomic status (SES) and the apolipoprotein E (APOE) e4 allele. In addition, our work will focus on issues to do measurement of health behaviors: Detailed attention will be paid to the categorization of the health behaviors in order to understand the shape of the association between each measure of behavior and cognitive aging, whether different measures diet have similar associations with cognitive aging and whether there are discrepancies between the objective and subjective measures of physical activity. We will also examine the impact of health behaviors on specific domains of cognitive aging, with memory and executive function as two major aspects. The Whitehall II test battery was introduced to the full Whitehall II cohort at phase 5 when participants were on average 55 years old and had already been assessed for behaviors over the previous 10 years. A third wave of cognitive data is currently being collected, and will be available late 2009, allowing us look at trajectories of cognitive change. Although the proposal is based primarily on the British Whitehall, the research team is composed of scientists based in France as well as the UK, providing us with the opportunity to validate some of our results in data from the French GAZEL study.