FASEB SRC: Genetic Recombination and Genome Rearrangements

描述(申请人提供)：本申请寻求部分支持美国实验生物学学会联合会(FASEB)关于基因重组和基因组重排的会议，会议将于2013年7月21-26日在科罗拉多州斯普林斯举行。2013年会议将是专门讨论这些专题的一系列非常成功的半年期会议中的第十五次。这次会议的目的是与研究人员一起研究基因重组的许多不同方面，在一系列生物系统中，并使用不同的实验方法。演讲将介绍关于实地及时问题的新的和未发表的工作，并将包括所有参与者的讨论。FASEB会议为交流信息和技术提供了独特的机会，可以在整个重组领域欣赏和利用这些信息和技术。DNA重组和基因组重排对癌症具有双重意义。首先，许多参与重组机制和调控的基因/蛋白已经被鉴定为肿瘤抑制基因。因此，对这些基因/蛋白质的研究对于更好地理解癌症的病因和开发关键的生物标记物是至关重要的。其次，化疗或放疗引起的全身性或局部性DNA损伤分别构成抗癌治疗的主要方式。相关的DNA损伤类型包括DNA双链断裂和链间交联，而重组是修复这种损伤的中心细胞途径。因此，对这些修复过程的调节和机制的了解的增加也将为抗癌治疗的新策略提供信息，从而导致更有效的治疗。几个适时的问题将被讨论，包括乳腺癌易感基因BRCA2在重组调控中的作用以及重组在修复癌症治疗相关药物和辐射造成的DNA损伤中的作用。利用哺乳动物和其他模型遗传系统，还将讨论重组和修复因子的特征，这些因子是人类综合征的基础，具有癌症倾向、过早衰老、免疫功能障碍和神经退化。此外，还将讨论下一代测序方法的新见解。通过在中等规模的会议环境中强调真正特殊的研究，FASEB会议为重组领域的新老研究人员提供了交流信息、技术和观点的独特机会。

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 21-26, 2013 in Steamboat Springs, Colorado. The 2013 Conference will be the fifteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. DNA Recombination and Genome Rearrangements have a two-fold significance for cancer. First, many genes/proteins involved in the mechanisms and regulation of recombination have already been identified as tumor suppressor genes. Hence, studies with these genes/proteins are paramount for an improved understanding of the etiology of cancer and to develop critical biomarkers. Second, induction of systemic or localized DNA damage by chemotherapy or radiation, respectively constitute major modalities of anti-cancer treatment. The types of relevant DNA damages include DNA double-stranded breaks and interstrand crosslinks, and recombination is a central cellular pathway to repair such damage. Therefore, increased knowledge on the regulation and mechanism of these repair processes will also inform novel strategies of anti-cancer treatment leading to more efficacious treatment. Several timely issues will be discussed, including the role of the breast cancer susceptibility gene BRCA2 in the control of recombination and the role of recombination in repair of DNA damage caused by cancer treatment relevant drugs and radiation. Characterization of recombination and repair factors known to underlie human syndromes with propensity to cancer, premature aging, immune dysfunction and neurological degeneration will also be discussed, using mammalian and other model genetic systems. In addition, new insights from next generation sequencing approaches will be discussed. By emphasizing truly exceptional research in a modestly sized conference setting, the FASEB conference provides unique opportunities for the exchange of information, technology and perspective among new and established investigators in the recombination field.