Comprehensive Cancer Center Program at Fox Chase

描述（由申请人提供）：福克斯大通癌症中心是在新的领导下，自上次审查，并继续作为全国为数不多的独立的综合性癌症中心之一。该中心的使命是“战胜癌症，每天在大胆的科学发现、预防策略和富有同情心的癌症护理的协作实践中，调动卓越的心灵和头脑。“我们的愿景是成为癌症研究和医学领域公认的国家领导者，成为费城地区杰出的癌症中心。新的领导层与外部咨询委员会的建议相结合，将CCSG研究计划从11个合并为5个。这五个项目代表了福克斯蔡斯癌症中心的核心科学优势。在最近一次审查中，30个CCSG共享设施和2个支持要素（方案审查和监测系统以及方案特定研究）获得了供资批准，并建议合并设施。本提案要求为16个核心设施和2个支助单位提供部分支助。要求发展基金在CCSG资助周期内战略性地增加这5个研究项目的临界质量。提出了征聘21至30名新调查员和替代调查员的计划。在过去的CCSG周期中，招募了40名调查员，排除我们的17名最新招募人员，23名调查员中的19名（83%）在任命后的24个月内获得了1540万美元的同行评审资金。其中510万美元是由调查人员筹集的，他们得到了发展基金的部分支助。自上次提交以来，癌症研究馆已按计划于2010年完工，将为新的研究实验室提供所需的大部分空间。领导层的愿景包括通过战略重点投资增加团队科学的计划。这些机构投资的目的是扩大气候变化框架公约的研究组合，包括更多的“基于团队的”赠款，如计划项目赠款和SPORE。作为这些基石投资的直接结果，未来几年将提交几项基于团队的科学资助提案。为了满足未来主要研究者增加的需求，中心计划利用 800万美元的ARRA资金和510万美元的机构投资用于建设比较医疗设施（CMR）。自上次审查以来，气候变化框架公约实施了一个正式的审查机制，以评估和优先考虑其CCSG共享研究资源。由于这一评估过程，共享研究资源的数量得到了精简。

DESCRIPTION (provided by applicant): The Fox Chase Cancer Center is under new leadership since the last review and continues as one of the nation's few free standing comprehensive cancer centers. The Center's mission is "To prevail over cancer, marshaling excellence of heart and mind each day in the collaborative practice of bold scientific discovery, prevention strategies, and compassionate cancer care." Our vision is to be an acknowledged national leader in cancer research and medicine and a pre-eminent cancer center in the Philadelphia area. The new leadership in conjunction with advice from External Advisory Boards has consolidated the CCSG Research Programs from 11 to 5. These five Programs represent the core scientific strengths of the Fox Chase Cancer Center. At the last review 30 CCSG Shared Facilities and 2 support elements (Protocol Review and Monitoring System and Protocol Specific Research) were approved for funding with recommendations to consolidate facilities. This proposal requests partial support for 16 core facilities and 2 support elements. Developmental Funds are requested to strategically increase critical mass for these 5 research Programs over the CCSG funding cycle. A plan is presented to recruit 21 to 30 new and replacement investigators. In the past CCSG cycle, 40 investigators were recruited and, with the exclusion of our 17 newest recruits, 19 of 23 (83%) have obtained $15.4 million in peer-reviewed funding within 24 months of their appointment. Of that amount $5.1 million was garnered by investigators who were partially supported by Developmental Funds. Since the last submission, the Cancer Research Pavilion was completed as planned in 2010 and will provide much of the needed space for new investigator laboratories. The Leadership's vision includes a plan to increase team-based science via strategic keystone investments. These institutional investments are intended to expand the research portfolio of FCCC to include more "team-based" grants such as Program Project Grants and SPOREs. Several team-based science grant proposals will be submitted over the next few years as a direct result of these keystone Investments. To meet the demand presented by a future increase in principal investigators, the Center plans to leverage $8 million of ARRA funds with $5.1 million of institutional investment to construct a Comparative Medical Facility (CMR). Since the last review, FCCC has implemented a formal review mechanism to evaluate and prioritize its CCSG Shared Research Resources. As a result, of this evaluation process, the number of Shared Research Resources has been streamlined.