Developmental Determinants of Cardiovascular Disease

描述（由申请人提供）：这是范德比尔特大学医学院儿科心脏病科和小门罗卡雷尔的一项新的T32申请。范德比尔特的儿童医院我们的长期目标是建立在该部门在培训学术儿科心脏病专家方面的成功基础上，通过开发一个计划，将心血管疾病发育决定因素研究的正式培训与儿科心脏病学的临床培训相结合。该培训计划不仅关注先天性心脏病的分子和遗传病因，还将强调产前和产后发育对定义出生后儿科心血管疾病表现的影响。除了儿科心脏病学的实习生外，相关儿科亚专业的临床研究员，如肺部医学，重症监护医学和新生儿医学以及博士学位。表示有兴趣研究心血管疾病发展机制的博士后研究员将有资格获得支助。该计划将为学员提供一个独特的机会，研究在儿童或成年后出现的心血管病理个体发育中正常发育过程的重演。该计划将由两个轨道组成，用于（1）基础科学研究或（2）临床或转化研究的准备。一个有针对性的教学互动的重点实验室经验将量身定制，以满足那些追求更基础的科学事业的需求。对于追求临床或转化医学职业生涯的学员，范德比尔特临床研究（MSCI）计划理学硕士将是培训计划的一个组成部分。候选人将主要从儿科心脏病学奖学金申请人中确定（2010年2个职位102名申请人）。这项建议将为第二年和第三年的研究金提供资金，在此期间，受训人员将在指导下进行研究。在第四年，受训者将完成临床培训，并可选择在子专科进行高级培训，以及继续研究和提交K 08或K23申请。该部和该司承诺为第一年和第四年的培训提供资金。项目负责人将使用一个内部咨询委员会，由范德比尔特内部成功的医生-科学家组成，以及一个外部咨询委员会，包括临床和基础研究专家，他们也是目前T32在儿科心脏病学应用的项目负责人。利用范德比尔特大学在发育生物学，血管生物学，再生医学和组织工程，心血管药理学和药物遗传学，人口以及基于结果的研究领域的独特优势，该计划将有助于培养下一代医生科学家。通过包括前学员作为导师在培训，该计划将协助这些初级教师在他们的学术生涯，以及保持导师的干部，为这个计划的未来成功。

DESCRIPTION (provided by applicant): This is a new T32 application from the Division of Pediatric Cardiology of the Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt. Our long- term goal is to build upon the success of the Division in training academic pediatric cardiologists by developing a program that integrates formal training in research on developmental determinants of cardiovascular disease with clinical training in pediatric cardiology. This training program will not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the impact of pre- and postnatal development in defining the manifestations of pediatric cardiovascular disease after birth. In addition to trainees in the Pediatric Cardiology, clinical fellows in related Pediatric subspecialties such as Pulmonary Medicine, Critical Care Medicine, and Neonatology as well as Ph.D. post-doctoral fellows who have an expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for support. This program will provide a unique opportunity for trainees to study the recapitulation of normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic science investigation or (2) clinical or translational research. A focused laboratory experience with targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career. For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical Investigation (MSCI) program will be an integral part of the training program. Candidates will primarily be identified from the pool of applicants for pediatric cardiology fellowship (102 applicants for 2 positions in 2010). This proposal will fund the second and third years of fellowship, during which the trainee will carry out the mentored research. During the fourth year, the trainee will complete clinical training with the option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or K23 application. The Department and Division are committed to funding the first and fourth years of this training. The program directors will use an internal advisory committee, comprised of successful physician-scientists from within Vanderbilt, as well as an external advisory committee that includes experts in both clinical and basic research who are also program directors for current T32 applications in Pediatric Cardiology. Using the unique strengths of Vanderbilt University in the areas of developmental biology, vascular biology, regenerative medicine and tissue engineering, cardiovascular pharmacology and pharmacogenetics, and population as well as outcomes based research, the program will help train the next generation of physician scientists. By including former trainees as Mentors-in-training, the program will assist these junior faculty members in their academic careers as well as maintain a cadre of mentors for the future success of this program.