FASEB SRC on Glucose transport: Gateway for metabolic systems Biology

描述(申请人提供)：简单的单糖葡萄糖是整个生物界能量和碳的主要来源。在哺乳动物中，循环中的葡萄糖浓度维持在一个非常窄的临界范围内，而血糖水平的紊乱是2型糖尿病的主要病理生理表现。此外，葡萄糖衍生的能量被解析为特定的细胞功能，如生长、增殖和维持，而癌细胞的生长严重依赖于葡萄糖依赖的途径。在葡萄糖转运领域已经取得了重大进展，例如阐明了葡萄糖转运蛋白的原子结构，以及在临床环境中产生和使用选择性的葡萄糖重摄取抑制剂。然而，许多问题仍然存在，对疾病机制的进一步影响取决于对能量代谢及其调节的更广泛背景下的葡萄糖运输的了解。本申请旨在为参加2013年美国科罗拉多州斯诺马斯村举行的2013年FASEB科学研究会议“葡萄糖运输：代谢系统生物学的门户”的年轻研究人员寻求住宿和旅行方面的支持。20年来，这次会议一直是参与葡萄糖运输研究的科学家们面对面讨论新发现、新问题和新出现的实验方法的最重要机会，这些新发现、新问题和新出现的实验方法解决了葡萄糖运输及其巨大的生理影响。这次会议的具体目标是：1)在全身代谢复杂性和疾病的背景下，整合不同的方法来理解葡萄糖的运输和代谢；2)吸引新的研究人员进入复杂而重要的葡萄糖和能量代谢领域。现代的方法包括假设驱动的发现和屏幕驱动的发现，后者涉及生成复杂的数据库和工具，以实现假设检验。此外，当前的能量代谢概念必须考虑微生物组的多个基因组的影响，这些基因组在人体内的不同位置相互作用。从原子机制到葡萄糖运输和能量代谢的系统生物学的八个会议被提出，由每个领域经验丰富的领先研究人员主持。为了确保及时讨论新出现的信息，该计划将从摘要中选择约30%的内容，并将支持来自该领域代表性不足群体的年轻调查人员和科学家的参与。

DESCRIPTION (provided by applicant): The simple monosaccharide glucose is the primary source of energy and carbon throughout the biological world. In mammals, the circulating concentration of glucose is maintained within a very narrow critical range, and disruption of glucose levels is the central pathophysiological manifestation of Type-2 diabetes. Moreover, glucose-derived energy is parsed into specific cellular functions such as growth, proliferation and maintenance, and cancer cell growth is critically dependent on glucose-dependent pathways. There has been major progress in the field of glucose transport, exemplified by the elucidation of the atomic structure of glucose transporters, and the generation and use of selective inhibitors of glucose reuptake in clinical settings. However, many questions remain, and further impact on disease mechanisms is contingent upon understanding glucose transport within the wider context of energy metabolism and its regulation. This application seeks support for housing and travel for young investigators to attend the 2013 FASEB Science Research Conference "Glucose transport: Gateway for Metabolic Systems Biology" July 14-19, 2013, Snowmass Village, Colorado, USA. For 20 years this conference has been the single most important opportunity for scientists involved in the study of glucose transport to meet face to face to discuss new findings, arising questions, and emerging experimental approaches to the complex problem of glucose transport and its vast physiological repercussion. The specific aims of this conference are 1) To integrate diverse approaches to understanding glucose transport and metabolism within the context of whole-body metabolic complexity and disease, and 2) To attract new investigators into the complex and important field of glucose and energy metabolism. Modern approaches include hypothesis-driven and screen-driven discovery, the later involving the generation of sophisticated databases and tools to enable hypothesis testing. In addition, current concepts of energy metabolism must account for the effects of multiple genomes of the microbiome, interacting at different niches within the human body. Eight sessions spanning from atomic mechanisms to systems biology of glucose transport and energy metabolism are proposed, chaired by experienced, leading investigators in each field. To insure timely discussion of emerging information, approximately 30 percent of the program will be chosen from abstracts, and participation by young investigators and scientists from groups underrepresented in the field will be favored.