2013, 2014 and 2015 Mammary Gland Biology Gordon Research Conference & Gordon Res

描述(由申请者提供)：本申请旨在为2013年乳腺生物学戈登研究会议(GRC)和戈登研究研讨会(GRS)提供资金支持。这一由来已久的会议的独特贡献和意义在于，它将汇集发育生物学家、干细胞生物学家、哺乳期生理学家、乳腺病理学家、内分泌学家、癌症生物学家和肿瘤学家，共同努力解决乳腺生物学和乳腺癌的重要问题。2013年成功项目的目标是启发重要见解，激励新科学家，促进创造性合作，加深我们对正常乳腺生理的理解，加快乳腺癌的根除。2013年会议的具体目标将是1)提供一个高资质、国际公认的演讲者计划，以解决当前的科学问题和争议；2)促进讨论、自由对话和促进合作；3)为年轻科学家的培训和发展做出贡献。2013年的项目旨在研究乳腺发育和癌症发生中令人兴奋、有时也有争议的领域，这些领域正在迅速取得进展。这些包括1)糖尿病/肥胖对乳腺发育、哺乳生理和乳腺癌的影响，2)更好地了解调控正常发育和癌变的信号通路，3)干细胞/祖细胞规格和肿瘤起始细胞的新出现的争议，4)乳腺细胞分化和乳腺癌的表观遗传调控，5)乳腺癌的侵袭和转移。这些都是重要的问题，在同一主题会议中将发展与癌症的研究配对的创新方法将激发新的创造性思维。这次会议的其他独特之处包括：(I)分享未发表数据的传统；(Ii)包括大量时间进行提问和公开讨论的计划；(Iii)支持在正式报告之外进行非正式讨论的环境；(Iii)通过戈登研究研讨会和戈登研究会议为学生和博士后提供积极参与和培训的环境；以及(Iv)鼓励国际合作和观点。

DESCRIPTION (provided by applicant): This application seeks funding support for the 2013 Mammary Gland Biology Gordon Research Conference (GRC) and Gordon Research Seminar (GRS). The unique contribution and significance of this long-standing conference is that it will bring together developmental biologists, stem cell biologists, lactation physiologists, breast pathologists, endocrinologists, cancer biologists and oncologists to collectively grapple with important issues in mammary biology and breast cancer. The goals for a successful 2013 program are to inspire important insights, energize new scientists and foster creative collaborations that will deepen our understanding of normal breast physiology and accelerate the eradication of breast cancer. The specific aims of the 2013 meeting will be to 1) provide a program of highly qualified, internationally recognized speakers to address current scientific questions and controversies, 2) foster discussion, unfettered dialog and promote collaborations, and 3) contribute to the training and development of young scientists. The 2013 program has been designed to examine exciting and sometimes controversial areas within mammary gland development and carcinogenesis in which rapid advances are occurring. These include 1) the influence of diabetes/obesity on mammary development, lactation physiology and breast cancer, 2) a better understanding of signaling pathways that regulate both normal development and carcinogenesis, 3) emerging controversies in stem/progenitor cell specification and in tumor initiating cells, 4) the epigenetic regulation of breast cell differentiation and breast cancer, an 5) breast cancer invasion and metastasis. These are important issues, and the innovative approach of pairing research into development and cancer within the same thematic sessions will stimulate new and creative thinking. Other unique features of this meeting include: (i) a tradition of sharing unpublished data; (ii) a program that includes substantial time for questions and open discussion, (iii) an environment that supports informal discussions outside of formal presentations; (iii) active participation and training environment for students and post-docs through the Gordon Research Seminar and at the Gordon Research Conference; and (iv) the encouragement of international collaborations and perspectives.