Adaptive Intervention Strategies: Advancing Research and Career Development

描述(由申请人提供)：拟议的K24的目的是：i)促进申请人在个人化或适应性指示的预防策略研究方面的研究，以解决轻、中度青少年药物参与问题；ii)指导和培训青少年肥皂水和相关行为障碍健康方面的下一代科学家，他们将从预防干预的角度进行研究。指导计划将在预防科学的高级主题方面培训四名已经确定的早期职业生涯、临床导向的研究人员，并促进他们在指定的预防模式下开发和测试个性化或适应性干预策略(AIS)的专业知识。人工智能是基于经验的决策规则，其中提供给参与者的干预计划(类型、剂量或成分序列)基于参与者对干预的响应(即主要定制变量)和/或在干预之前评估的个体特征(即， 二次调整变量)。此外，培训和研究将侧重于轻度-中度药物使用青少年(根据DSM-IV定义的滥用或拟议的DSM-5定义的轻度物质使用障碍)，目的是戒除或阻止向依赖发展。

DESCRIPTION (provided by applicant): The purpose of the proposed K24 is to i) advance the research of the applicant in the study of personalized or adaptive indicated prevention strategies to address mild-moderate adolescent drug involvement and ii) mentor and train the next generation of scientists in adolescent SUDs and related behavioral disorders health who will conduct research from a preventive intervention perspective. The mentoring program will train four, already identified, early career, clinically-oriented researchers in advanced topics in prevention science and facilitate their expertise in developing and testing of personalized or adaptive intervention strategies (AIS) within an indicated prevention model. AIS are empirically-based decision rules in which the intervention plan (type, dosage, or sequence of components) offered to participants is individualized based on participants' response to the intervention (i.e. primary tailoring variable) and/or individual characteristics assessed prior to intervention (i.e., secondary tailoring variables). Furthermore, training and research will focus on mild- moderate drug using teenagers (abuse as defined by DSM-IV or mild substance use disorder as defined by proposed DSM-5), with the aim of abstinence or halting progression to dependence.