The National Drug Abuse Treatment Clinical Trials Network

描述（由申请人提供）：响应RFA-DA-10-009，本申请寻求更新国家药物滥用治疗临床试验网络（CTN）的太平洋地区节点，以继续提高成瘾治疗的质量和交付，这些治疗可以由社区治疗提供者（CTPs）有效地实施。由Walter Ling博士领导的太平洋地区节点正在进行和未来的研究、培训和传播活动，将服务于CTN的使命，“以科学为载体，提高全国药物滥用治疗的质量”。该节点将继续通过其领导和参与创新概念的开发、严格的研究行为、高效的管理和有效的CTN产品传播，为CTN的努力做出重大贡献。例如，在最近的资助期内，节点参与者制定了两项协议，目前领导CTN0048，丁丙诺啡减少可卡因使用（CURB）的协议制定。节点人员将继续开发和传播培训材料和手册，供整个CTN使用，计划和主持面向CTN的会议，并通过培训、演讲、出版物和基于互联网的方法传播基于CTN的发现。该节点的活动将通过与全球其他节点、CTN ctp以及其他供应商和研究人员合作的方式，推进科学发展，并增加研究证实治疗的广泛实施。这一更新建议在现有的五个ctp基础上增加两个ctp，增加地理分布和种族/民族包容性，并确保能够接触到每一个可能的环境、模式、特殊人群和药物滥用问题。太平洋区域节点打算加快新药物和行为疗法的开发和测试，这些药物和行为疗法可以综合起来取得更好的结果。创新、研究速度和相关性将通过增加与提供者团体和研究潜在疗法的研究人员的互动，利用Node的现有伙伴关系，同时建立新的合作关系，并涉及更广泛的环境而得到加强。太平洋区域节点的更新将通过与NIDA、CTN参与者和其他利益攸关方的合作，加强CTN的努力。

DESCRIPTION (provided by applicant): Responding to RFA-DA-10-009, this application seeks renewal of the Pacific Region Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) to continue improving the quality and delivery of addiction treatments that can be implemented efficiently by community-based treatment providers (CTPs). The ongoing and future research, training, and dissemination activities of the Pacific Region Node, led by Walter Ling, M.D., will serve the CTN mission "to improve the quality of drug abuse treatment throughout the country, using science as a vehicle." The Node will continue to contribute significantly to the CTN effort by its leadership and participation in innovative concept development, rigorous conduct of research, efficient management, and effective dissemination of CTN products. In the most recent funding period, for example, Node participants developed two protocols and currently lead protocol development of CTN0048, Cocaine Use Reduction with Buprenorphine (CURB). Node personnel will continue to develop and disseminate training materials and manuals for use across the CTN, to plan and host CTN-oriented conferences, and disseminate CTN-based findings through trainings, presentations, publications, and Internet-based methods. The Node's activities will advance the science and increase broad implementation of research-proven treatments in a collaborative manner with other nodes, CTN CTPs, and other providers and researchers worldwide. This renewal proposes adding two CTPs to the existing five, increasing geographic presence and racial/ethnic inclusion as well as ensuring access to every possible setting, modality, special population, and drug abuse problem. The Pacific Region Node intends to accelerate development and testing of new medications and behavioral therapies that can be integrated to achieve better outcomes. Innovation, research pacing, and relevance will be enhanced by increasing interaction with provider groups and with researchers examining potential therapies, exploiting the Node's existing partnerships while building new collaborations and involving more broad-based settings. Renewal of the Pacific Region Node will strengthen CTN efforts through collaborative work with NIDA, CTN participants, and other stakeholders.