Database and Drug Interaction Core

数据库和药物相互作用的核心 迫切需要一个数据库，其中包含有关滥用药物组合的相关量化信息。坦普尔大学药物滥用研究中心(CSAR)建议将这一努力作为该中心活动的一项新的核心活动，该活动将由RJ·塔拉里达指导。塔拉里达博士在药物组合领域进行了广泛的研究并发表了文章，这一努力，加上他在世界范围内发表的大量关于药物组合的出版物，是这次赠款续期申请中新的组成部分的基础。许多药物组合因其批准的用途以及在街头的使用而广为人知(例如，芬太尼+可卡因、海洛因+甲基苯丙胺等，以及涉及酒精或大麻的广泛组合)。我们建议增加这项核心活动，以开发一个数据库，该数据库来源于实验室研究和人类使用出版物，其中包括具有特殊意义的药物组合。我们指的是合法的医疗使用药物组合以及常见的“街头组合”。主要目标是在世界范围内搜索并将相互作用分类为协同作用、次相加作用或简单相加作用。这将通过我们的药物滥用研究中心新创建的网站实现，所有人都可以访问该网站。研究药物滥用组合的调查人员通常以对街头使用中常见的药物组合的认识为指导。这种药物滥用的模式在执法和监管机构中是众所周知的，而且有充分的文件证明，许多--事实上，所有的--都是潜在的危险组合。当药物在某些有毒终点协同作用时，危险就会增加。因此，特别重要的是掌握关于这些被娱乐和非法使用的代理人之间这种不寻常的相互作用的准确定量信息。

DATABASE & DRUG INTERACTIONS CORE There is a pressing need for a data base that contains relevant quantitative information on combinations of drugs of abuse. The Center for Substance Abuse Research (CSAR) of Temple University is proposing this effort as a new core activity in the Center activities that will be directed by RJ Tallarida. Dr. Tallarida has studied and published extensively in the area of drug combinations That effort, coupled with his numerous worldwide publications on drug combinations, is the basis of new component in this grant renewal application. Many drug combinations are well known for their approved use as well as their use on the street, (e.g., fentanyl + cocaine, heroin + methamphetamine, etc, and extensive combinations that involve alcohol or marijuana). We propose the addition of this core activity that will undertake the development of a data base derived from publications of laboratory-based studies and human use that include drug combinations of special relevance. By that we mean the legitimate medical use of a drug combination as well as common "street combinations". The main objective is to search world wide and classify interactions as synergistic, sub-additive or simply additive. This will be accomplished from a newly created website, accessible by all, from our Center on Substance Abuse Research Investigators who study combinations of drugs of abuse are usually guided by awareness of those combinations that are common in street use. The patterns of such drug abuse are well known among law enforcement and regulatory agencies, and it is well documented that many-in fact, all, are potentially dangerous combinations. The danger is enhanced when the drugs interact synergistically in some toxic endpoint. It is therefore especially important to have precise quantitative information on such unusual interactions among these agents that are used recreationally and illegally.