Project 2- Attention and Dual Task Interference

项目总结(见说明)； 项目2：注意和双重任务干扰我们继续使用翻译行为 将具有更大分析能力的范例引入精神分裂症注意力研究的科学战略。这个 加州大学圣地亚哥分校的Pashler博士与加州大学洛杉矶分校的临床研究人员Nuechterlein博士和Subotnik博士之间的合作 得到了强有力的证据，支持在注意力分散的情况下结构性加工瓶颈的特定模型 精神分裂症。除此之外，精神分裂症患者中存在明显结构处理瓶颈的部位 在反应选择过程和反应产生过程中孤立。因此，在感知编码的同时 正常进行，不会对精神分裂症患者造成双重任务干扰，反应选择 一个任务中的过程和反应产生(运动)过程明显地干扰了另一个任务的完成。 虽然双重任务干扰的许多方面在疾病的各个阶段都是异常的，但 异常严重的处理瓶颈倾向于从先兆进展到后期 精神分裂症。运动干扰也预示着以后的工作独立于记忆和社交活动。 认知缺陷，表明它具有独特的作用。在该项目的下一阶段，有几个新步骤 建议。首先，为了将记忆项目的结果与这个关注项目的结果结合起来，我们将 检查声明性记忆过程是否以某种方式干扰其他同时处理 在精神分裂症中涉及一个特别严重的结构性处理瓶颈。第二，我们将延长 这个项目的结果是涉及带有享乐主义后果的动机决策的情况，而不是 只有简单的预先指定的回答选择。第三，我们会进一步研究政府的贡献是否 运动过程对注意障碍和功能结局的贡献不同于记忆 流程。最后，我们将检查特定处理瓶颈的指标在多大程度上 精神分裂症是功能能力的贡献者，并通过它促进日常功能水平

PROJECT SUMMARY (See instructions); PROJECT 2: ATTENTION AND DUAL-TASK INTERFERENCE We continue to use a translational behavioral science strategy to bring paradigms with greater analytic power to the study of attention in schizophrenia. The collaboration between Dr. Pashler of UCSD and clinical researchers Drs. Nuechterlein and Subotnik of UCLA has yielded strong evidence in favor of specific models of structural processing bottlenecks in divided attention in schizophrenia. Beyond this, sites of marked structural processing bottlenecks in schizophrenia have been isolated in response selection processes and response production processes. Thus, while perceptual encoding proceeds normally without causing dual-task interference in schizophrenia patients, response selection processes and response production (motoric) processes in one task markedly interfere with doing another task. While many aspects of dual-task interference are abnormal across phases of illness, some component of an abnormally severe processing bottleneck tend to progress in severity from prodromal to later phases of schizophrenia. Motoric interference also predicts later work functioning independently from memory and social cognition deficits, suggesting that it has a distinctive role. In the next phase ofthis project, several new steps are proposed. First, to integrate findings in the memory project with the findings ofthis attention project, we will examine whether declarative memory processes interfere with other simultaneous processing in a way that involves a particularly severe structural processing bottleneck in schizophrenia. Second, we will extend the findings ofthis project to situations that involve motivated decisions with hedonic consequences, rather than only simple pre-designated response selections. Third, we will examine further whether the contribution of motor processes to attentional dysfunction and functional outcome is distinct from the contribution of memory processes. Finally, we will examine the extent to which indicators of particular processing bottlenecks in schizophrenia serve as contributors to functional capacity and through it contribute to everyday functional leve