Center for Psychiatric Neuroscience

描述（由申请人提供）：抑郁症是全球疾病负担的第三大贡献者;酒精和非法药物使用是造成这一负担的十大贡献者之一（世界卫生组织全球疾病负担：2004年更新）。在COBRE资助的十年中，密西西比大学医学中心（UMMC）的精神神经科学中心（CPN）开发了尖端的核心设施，并将其重点扩展到抑郁症和酒精依赖领域。创新和多学科中心的研究人员合作，对神经元和神经胶质，脑血管，衰老，性别，转录因子，血清素和谷氨酸在抑郁症和酗酒中的作用进行了开创性的观察，许多人获得了独立的资金。我们在第三阶段的使命是通过促进指导，加强研究核心，继续建立精神疾病和精神活性物质使用障碍的病理生理学基础研究，从而增加密西西比的NIH资金。实现这一使命的具体目标是：1）提供支持，以维持和扩大国家的最先进的研究核心，这是必不可少的，以支持整个机构和国家的基础研究，2）促进合作和多学科的指导环境，支持创新的试点研究，和3）发展一个自我维持的生物医学研究卓越中心，由赞助商发起的研究赠款和合作计划项目支持。我们的协同研究核心，可在整个机构和全州范围内提供给其他COBRE和INBRE研究人员，将允许指导项目的发展沿着使用成像核心和分子和基因组学核心的轨迹来量化疾病-在动物行为核心中对这种病理进行建模，以开发精神病理学的表型模型，并探索新的治疗方法，抑郁症和精神活性物质使用障碍，包括酒精依赖。最先进的研究核心将支持有指导的基础研究，以寻求预防和治疗这些全球心理健康挑战的新战略。

DESCRIPTION (provided by applicant): Depression is the 3rd leading contributor to the global burden of disease; alcohol and illicit drug use are among the top ten contributors to that burden (World Health Organization The Global Burden of Disease: 2004 Update). In ten years of COBRE funding, the Center for Psychiatric Neuroscience (CPN) at The University of Mississippi Medical Center (UMMC) developed cutting-edge core facilities and expanded its focus to the areas of depression and alcohol dependence. Innovative and muitidisciplinary Center investigators have collaborated in ground breaking observations on the roles of neurons and glia, cerebral vasculature, aging, gender, transcription factors, serotonin and glutamate in depression and alcoholism and many have secured independent funding. Our mission in Phase III is to continue building basic research in the pathophysiology of mental illnesses and psychoactive substance use disorders by promoting mentoring, strengthening research cores and, thereby, to increase NIH funding in Mississippi. Specific Aims toward reaching this mission are to: 1) provide support to maintain and expand state-of-the-art research cores that are essential to support basic research across the institution and the state, 2) promote a collaborative and muitidisciplinary mentoring environment that supports innovative pilot research, and 3) develop a self-sustaining center of biomedical research excellence supported by investigator-initiated research grants and collaborative program projects. Our synergistic research cores, available across the institution and state-wide to other COBRE and INBRE investigators, will permit the development of mentored projects along a trajectory of using the Imaging Core and the Molecular and Genomics Core to quantify disease-specific pathology in tissues from the Postmortem Brain Core and modeling such pathology in the Animal Behavior Core to develop phenotypic models of psychopathology and explore novel treatments for depression and psychoactive substance use disorders, including alcohol dependence. State-of-the-art research cores will support mentored basic research in search of new strategies of prevention and treatment for these global challenges to mental health.