Trauma Molecular Pathogenesis and Regeneration Training Grant

描述（由申请人提供）：本申请寻求支持在创伤医学领域建立一个新的博士后培养计划。该计划的动机是在分子发病机制和损伤治疗方面不断发展的跨学科综合基础、临床和转化研究，是芝加哥大学组织损伤和修复方面成熟的正式研究生课程（附录I-3）和研究项目的产物。我们的计划增长是由新的分子再生创伤疗法的研究进展所产生的巨大的潜在临床影响所驱动的，细胞膜和蛋白质结构的分子再生作为创伤研究的一种方法在21年前开始于芝加哥大学，现在已经广泛验证并成为一个自我维持的研究领域。今天，各种大学和公司都有足够的衍生研究来证明正式的教育计划是合理的。逆转创伤的后果需要恢复失去的膜屏障功能，改造天然大分子结构，控制氧生物化学，修复核酸，重建代谢能量电荷。这个新领域的新研究者必须具备细胞生理学、膜生物物理学、蛋白质化学、氧生物化学、核酸修复、动物研究方法、临床研究指南以及分子功能的计算和诊断成像方面的能力。拟议的培训计划符合这些要求。芝加哥大学生物科学系是开展此类培训项目的理想场所。首先，该大学拥有完善的、资金充足的研究项目，涵盖了上述所有领域，甚至更多。这里的研究工作是跨学科和综合的，为发现奠定了基础。提案中详细介绍了许多最先进的核心设施。此外，学员将有机会使用美国国立卫生研究院最近资助的超级计算机，该计算机具有生物医学领域前所未有的能力，可以模拟创伤的分子动力学和合成伴侣的行为，以再生正常的分子结构。此外，我们已经有了多年的教学历史，现在要求研究生课程特别关注细胞损伤，由培训项目导师共同教授。

DESCRIPTION (provided by applicant): This application seeks support to establish a new post-doctoral training program in the field of trauma medicine. The program is motivated by the growing integrative cross-disciplinary basic, clinical and translational research in the molecular pathogenesis and treatment of injury and is the outgrowth of well-established formal graduate courses(Appendix I-3) and research programs in tissue injury and repair at the University of Chicago. Our programmatic growth is driven by the large potential clinical impact resulting from research advances into new molecular regeneration trauma therapies, Molecular regeneration of cellular membranes and protein structure as an approach to trauma research had its beginnings at the University of Chicago more than 21 years ago and has now widely validated and emerging as a self-sustaining field of research . Today, there is sufficient established derivative research across various universities and companies to justify a formal educational program. Reversing the consequences of trauma requires recovery of the lost barrier function of membranes, reformation of native macromolecular structure, control of oxygen biochemistry, nucleic acid repair, and reestablishment of metabolic energy charge. New investigators in this new field must have competences in cellular physiology, membrane biophysics, protein chemistry, oxygen biochemistry, nucleic acid repair, animal research methods, clinical research guidelines, as well as computational and diagnostic imaging of molecular function. The proposed training program meets these requirements. The University of Chicago's Biological Sciences Division is an ideal site to launch such a training program. First, the University has well established and well funded research programs covering all of the mentioned areas mentioned and more. The research efforts here are interdisciplinary and integrated, setting the stage for discovery. There are many state of the art core facilities that are detailed in the proposal. Moreover, trainees will have access to a recently NIH grant funded super-computer with capabilities unprecedented in biomedicine to model molecular dynamics of trauma and behavior of synthetic chaperones to regenerate normal molecular structure. In addition, we already have in place a multi-year history of teaching now required graduate courses specifically focused on cell injury co-taught by the training program mentors.