Core A - Bioimaging Core

项目摘要(参见说明)：该核心旨在提供定量磁共振成像(MRI)、图像定位光谱(MRS)、光谱成像(MRSI)和单光子发射计算机断层扫描/X射线计算机断层扫描(SPECT/CT)，用于体内细胞和药物的生物分布和疗效分析。项目支助包括纳米材料生物分布的药代动力学测量(项目6、7、9、10)、疾病进展/药物疗效的测量(项目7)和组织灌注量测量(项目7)。此外。核心教员将参与培训新的研究人员，了解可用的方法，以加快纳米医学效应的体内研究。方法包括心脏和血管功能、肿瘤形态和灌注、扩散张量成像和磁共振波谱(MRS)，包括31P MRS和IHMRS。其中一些方法已经被其他纳米医学研究人员广泛用于研究疾病的影响和纳米制剂改善这些变化的能力。这些能力将对纳米医学计划的总体推进以及满足当前和未来NCN教员的需求至关重要

PROJECT SUMMARY (See instructions): This core is designed to provide quantitative magnetic resonance imaging (MRI), image localized spectroscopy (MRS), spectroscopic imaging (MRSI) and single photon emission computed tomography/Xray computed tomography (SPECT/CT) for in-vivo assays of cell and drug biodistribution and efficacy. Project support includes pharmacokinetic measures of nanomaterial biodistribution (Projects 6, 7, 9, 10), measures of disease progression/drug efficacy (Project 7), and tissue perfusion measurements (Project 7). In addition. Core faculty will be involved in the training of new investigators on available methods to accelerate in-vivo studies of nanomedication effects. Methods including cardiac and vascular function, tumor morphology and perfusion, diffusion tensor imaging, and magnetic resonance spectroscopy (MRS), both 31P MRS and IH MRS, are available. Some of these methods have been extensively used by other nanomedicine researchers in investigations of the effects of disease and the ability for nanoformulations to ameliorate these changes. These abilities will be critical to the advancement of the nanomedicine program in general and the ability to meet the needs of current and future NCN faculty