LITHIUM-7 MR STUDIES OF RAT BRAIN AT 7 TESLA

7 特斯拉大鼠大脑的 LITHIUM-7 MR 研究

• 批准号: 7955667
• 负责人: MICHAEL Douglas BOSKA
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955667
• 关键词: Agreement; Area; Brain; Brain Mapping; Cell Nucleus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Development; Drug Kinetics; Funding; Goals; Gold; Grant; Institution; Ionizing radiation; Lithium; Magnetic Resonance; Manic; Maps; Measures; Methodology; Methods; Modeling; Pharmaceutical Preparations; Radiation; Radioisotopes; Rattus; Recurrence; Research; Research Personnel; Resources; Source; Staging; United States National Institutes of Health; absorption; computational anatomy; in vivo; nuclear Overhauser enhancement; response; spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lithium (Li) is efficacious in the treatment of bipolar illness and recurrent episodes of mania. Since Li is a CMS drug, its concentration in the brain might be expected to relate more closely to clinical response. The distribution of lithium in the brain is of importance in Li therapy and in localizing its action in the brain. Thus, an in vivo measure of brain Li concentration is necessary. Magnetic resonance (MR), a method that does not involve any ionizing radiation or radioactive isotopes, can be used to observe Li non-destructively in an in vivo setup. As a part of the overall goal to quantify and map brain lithium, we will develop Spectroscopic Imaging (SI) with nuclear Overhauser enhancement of Li nucleus under the limits of Specific Absorbed Radiation (SAR). Further developments will be undertaken using shorter brain only coil operating in the quadrature mode. Optimization of the method will include: a) volume localization and b) outer volume saturation prior to SI data collection. Li intensities in the rat brain will be measured using the most optimal method. The SI data are then corrected for Point Spread Function (PSF) induced intensity changes. Concentrations are obtained upon comparing the intensities with those from equivalent voxels from a phantom of known concentration. Finally, the MR method will be validated against the "gold standard" such as atomic absorption (AA) method and the agreement between the two methods established. The newly validated methodology will be used to map out Li distribution in the rat brain at different stages of Li passage through the brain. Regional pharmacokinetics will be studied from broad anatomical areas of relevance to bipolar illness.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 锂（Li）在治疗躁郁症和躁狂症复发发作方面有效。由于LI是一种CMS药物，因此可能预期其在大脑中的浓度与临床反应更加紧密相关。锂在大脑中的分布在LI疗法和将其在大脑中的作用定位至关重要。因此，必须对脑LI浓度进行体内测量。磁共振（MR）是一种不涉及任何电离辐射或放射性同位素的方法，可用于在体内设置中无损地观察LI。作为量化和映射脑锂的总体目标的一部分，我们将在特定吸收辐射（SAR）的范围内开发具有LI核的核过度大核增强的光谱成像（SI）。仅在正交模式下仅操作大脑的大脑将进行进一步的发展。该方法的优化将包括：a）体积定位和b）SI数据收集之前的外部体积饱和度。大鼠大脑中的LI强度将使用最佳方法测量。然后对SI数据进行校正以获得点扩散函数（PSF）诱导强度变化。将强度与来自已知浓度幻影的等效体素的强度进行比较时，获得了浓度。最后，将使用“黄金标准”（例如原子吸收方法（AA）方法以及建立的两种方法之间的一致性）来验证MR方法。新验证的方法将用于在Li通过大脑的不同阶段绘制大鼠大脑中的LI分布。将研究与双极疾病相关的广泛解剖区域进行研究。