LITHIUM-7 MR STUDIES OF RAT BRAIN AT 7 TESLA

7 特斯拉大鼠大脑的 LITHIUM-7 MR 研究

• 批准号: 8171058
• 负责人: MICHAEL Douglas BOSKA
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171058
• 关键词: Agreement; Area; Brain; Brain Mapping; Cell Nucleus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Development; Drug Kinetics; Funding; Goals; Gold; Grant; Institution; Ionizing radiation; Lithium; Magnetic Resonance; Manic; Maps; Measures; Methodology; Methods; Pharmaceutical Preparations; Radiation; Radioisotopes; Rattus; Recurrence; Research; Research Personnel; Resources; Source; Staging; United States National Institutes of Health; absorption; in vivo; nuclear Overhauser enhancement; response; spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lithium (Li) is efficacious in the treatment of bipolar illness and recurrent episodes of mania. Since Li is a CMS drug, its concentration in the brain might be expected to relate more closely to clinical response. The distribution of lithium in the brain is of importance in Li therapy and in localizing its action in the brain. Thus, an in vivo measure of brain Li concentration is necessary. Magnetic resonance (MR), a method that does not involve any ionizing radiation or radioactive isotopes, can be used to observe Li non-destructively in an in vivo setup. As a part of the overall goal to quantify and map brain lithium, we will develop Spectroscopic Imaging (SI) with nuclear Overhauser enhancement of Li nucleus under the limits of Specific Absorbed Radiation (SAR). Further developments will be undertaken using shorter brain only coil operating in the quadrature mode. Optimization of the method will include: a) volume localization and b) outer volume saturation prior to SI data collection. Li intensities in the rat brain will be measured using the most optimal method. The SI data are then corrected for Point Spread Function (PSF) induced intensity changes. Concentrations are obtained upon comparing the intensities with those from equivalent voxels from a phantom of known concentration. Finally, the MR method will be validated against the "gold standard" such as atomic absorption (AA) method and the agreement between the two methods established. The newly validated methodology will be used to map out Li distribution in the rat brain at different stages of Li passage through the brain. Regional pharmacokinetics will be studied from broad anatomical areas of relevance to bipolar illness.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 锂 (Li) 可有效治疗双相情感障碍和反复发作的躁狂症。由于 Li 是一种 CMS 药物，因此其在大脑中的浓度可能与临床反应更密切相关。锂在大脑中的分布对于锂疗法及其在大脑中的作用定位非常重要。因此，有必要对脑锂离子浓度进行体内测量。磁共振（MR）是一种不涉及任何电离辐射或放射性同位素的方法，可用于在体内装置中无损地观察锂。作为量化和绘制脑锂总体目标的一部分，我们将开发在比吸收辐射（SAR）限制下对锂核进行核欧沃豪瑟增强的光谱成像（SI）。将使用在正交模式下运行的较短的仅大脑线圈进行进一步的开发。该方法的优化将包括：a) 体积定位和 b) SI 数据收集之前的外部体积饱和。将使用最佳方法测量大鼠大脑中的锂强度。然后针对点扩散函数 (PSF) 引起的强度变化对 SI 数据进行校正。通过将强度与来自已知浓度体模的等效体素的强度进行比较来获得浓度。最后，MR 方法将根据原子吸收 (AA) 方法等“金标准”进行验证，并确定两种方法之间的一致性。新验证的方法将用于绘制锂在大鼠大脑中通过大脑的不同阶段的分布。将从与双相情感障碍相关的广泛解剖区域研究区域药代动力学。