Advanced Imaging for Glaucoma Study Optic Disc Reading Center

描述（申请人提供）：青光眼高级成像研究（AIGS）是一项前瞻性纵向多中心观察性研究，旨在测试高级成像技术的能力：扫描激光偏振法（SLP）、扫描激光断层摄影术（OCT）、时域光学相干断层摄影术（TD-OCT）、傅立叶域光学相干断层摄影术（FD-OCT），和多普勒傅立叶域光学相干断层扫描测量视网膜血流（多普勒OCT），以提高青光眼的早期检测和预测青光眼视野缺损的发展。 迈阿密大学米勒医学院/巴斯科姆帕尔默眼科研究所（BPEI）、匹兹堡大学医学中心（UPMC）和南加州大学/Doheny眼科研究所（USC）为临床中心。 协调中心和主席办公室位于俄勒冈州健康与科学大学（OHSU）。 项目主席大卫黄博士要求前高眼压治疗研究和协作初始青光眼治疗研究视盘阅读中心主任理查德帕里什博士建立青光眼高级成像-视盘阅读中心（AIGS-ODRC）。 依据是由三家临床中心的临床眼科医生进行的非均匀和未设盲的视盘评估结果。 我们建议通过评估现有的AIGS立体照片来实现五个具体目标：提供视盘特征的统一掩蔽并排读数，并确定视盘转换和进展终点~将临床中心的视盘转换和进展测定与ODRC的测定进行比较~将高级成像模式与视盘测定进行比较~比较先进的成像方式与视野结合视盘测定~创建一个数字数据库的视盘照片提供给研究人员。 的结果 AIGS-ODRC立体视盘评估是一种金标准、低成本、定性的技术，将与更昂贵和定量的先进成像技术所获得的结果进行比较。 公共卫生相关性：青光眼高级成像研究-视盘阅读中心将评估现有的立体视盘照片，以评价青光眼转换和进展。 将这种黄金标准、低成本、定性技术的结果与更昂贵和定量的先进成像技术（扫描激光偏振仪、扫描激光断层扫描仪、光学相干断层扫描仪）的结果进行比较。

DESCRIPTION (provided by applicant): The Advanced Imaging for Glaucoma Study (AIGS), a prospective longitudinal multicenter observational study was designed to test the ability of advanced imaging technologies: scanning laser polarimetry (SLP), scanning laser tomography (SLT), time domain optical coherence tomography (TD-OCT), Fourier domain optical coherence tomography (FD-OCT), and Doppler Fourier domain optical coherence tomography measurement of retinal blood flow (Doppler OCT) to improve the early detection of glaucoma and to predict the development of glaucomatous visual field defects. The University of Miami Miller School of Medicine/Bascom Palmer Eye Institute (BPEI), University of Pittsburgh Medical Center (UPMC), and the University of Southern California/Doheny Eye Institute (USC) are Clinical Centers. The Coordinating Center and Chairman's Office are located at Oregon Health and Science University (OHSU). Dr. David Huang, Project Chairman, asked Dr. Richard Parrish, former director of the Ocular Hypertension Treatment Study and Collaborative Initial Glaucoma Treatment Study Optic Disc Reading Centers to establish an Advanced Imaging for Glaucoma-Optic Disc Reading Center (AIGS-ODRC). The rationale was based on the results of non-uniform and unmasked optic disc assessments that were performed by clinical ophthalmologists at the three clinical centers. We propose to achieve five specific aims from assessment of existing AIGS stereoscopic photographs: provide uniform masked side by side readings of optic disc characteristics and determine optic disc conversion and progression endpoints~ compare the clinical centers' determination of optic disc conversion and progression with that of the ODRC~ compare advanced imaging modalities to optic disc determinations~ compare advanced imaging modalities to visual field combined with optic disc determinations~ create a digital database of optic disc photographs available to researchers. The results from the AIGS-ODRC stereoscopic optic disc assessment, a gold standard, low- cost, qualitative technique will be compared with the results obtained with the more expensive and quantitative advanced imaging technologies. PUBLIC HEALTH RELEVANCE: The Advanced Imaging for Glaucoma Study - Optic Disc Reading Center will assess existing stereoscopic optic disc photographs to evaluate glaucoma conversion and progression. The results from this gold standard, low-cost, qualitative technique will be compared with the results obtained with the more expensive and quantitative advanced imaging technologies (scanning laser polarimetry, scanning laser tomography, optical coherence tomography).