Comprehensive Cancer Center Program at Fox Chase

描述(由申请人提供)：狐狸大通癌症中心自上次审查以来处于新的领导之下，并继续作为全国为数不多的独立的综合性癌症中心之一。该中心的使命是“战胜癌症，在大胆的科学发现、预防策略和富有同情心的癌症护理的协作实践中，每天召唤优秀的心灵和心灵。”我们的愿景是成为公认的全国癌症研究和医学领先者，并成为费城地区卓越的癌症中心。新的领导层与外部顾问委员会的建议一起，将CCSG研究计划从11个整合到5个。这五个计划代表了福克斯·蔡斯癌症中心的核心科学实力。在上次审查中，核准了30个协调小组共享设施和2个支助要素(礼宾审查和监测系统和礼宾具体研究)的供资，并提出了合并设施的建议。这项提议要求为16个核心设施和2个支助部分提供部分支助。在CCSG资助周期内，要求发展基金战略性地增加这5个研究项目的临界质量。提出了招聘21至30名新调查员和替补调查员的计划。在过去的CCSG周期中，招聘了40名调查人员，不包括我们的17名新招聘人员，23名调查人员中有19名(83%)在受聘后24个月内获得了1,540万美元的同行审查资金。其中510万美元是由部分得到发展基金支持的调查人员获得的。自上次提交以来，癌症研究展馆按计划于2010年完工，将为新的研究实验室提供所需的大部分空间。领导层的愿景包括一项计划，通过战略Keystone投资增加基于团队的科学。这些机构投资旨在扩大联合国气候变化框架公约的研究范围，以包括更多的“基于团队”的赠款，如方案项目赠款和孢子。作为这些Keystone投资的直接结果，未来几年将提交几个基于团队的科学拨款提案。为了满足未来主要调查人员增加带来的需求，该中心计划利用 800万美元的ARRA资金和510万美元的机构投资，以建立一个比较医疗机构(CMR)。自上次审查以来，《气候变化框架公约》实施了一项正式审查机制，以评估其CCSG共享研究资源并确定其优先顺序。因此，在这一评价过程中，共享研究资源的数量得到了精简。

DESCRIPTION (provided by applicant): The Fox Chase Cancer Center is under new leadership since the last review and continues as one of the nation's few free standing comprehensive cancer centers. The Center's mission is "To prevail over cancer, marshaling excellence of heart and mind each day in the collaborative practice of bold scientific discovery, prevention strategies, and compassionate cancer care." Our vision is to be an acknowledged national leader in cancer research and medicine and a pre-eminent cancer center in the Philadelphia area. The new leadership in conjunction with advice from External Advisory Boards has consolidated the CCSG Research Programs from 11 to 5. These five Programs represent the core scientific strengths of the Fox Chase Cancer Center. At the last review 30 CCSG Shared Facilities and 2 support elements (Protocol Review and Monitoring System and Protocol Specific Research) were approved for funding with recommendations to consolidate facilities. This proposal requests partial support for 16 core facilities and 2 support elements. Developmental Funds are requested to strategically increase critical mass for these 5 research Programs over the CCSG funding cycle. A plan is presented to recruit 21 to 30 new and replacement investigators. In the past CCSG cycle, 40 investigators were recruited and, with the exclusion of our 17 newest recruits, 19 of 23 (83%) have obtained $15.4 million in peer-reviewed funding within 24 months of their appointment. Of that amount $5.1 million was garnered by investigators who were partially supported by Developmental Funds. Since the last submission, the Cancer Research Pavilion was completed as planned in 2010 and will provide much of the needed space for new investigator laboratories. The Leadership's vision includes a plan to increase team-based science via strategic keystone investments. These institutional investments are intended to expand the research portfolio of FCCC to include more "team-based" grants such as Program Project Grants and SPOREs. Several team-based science grant proposals will be submitted over the next few years as a direct result of these keystone Investments. To meet the demand presented by a future increase in principal investigators, the Center plans to leverage $8 million of ARRA funds with $5.1 million of institutional investment to construct a Comparative Medical Facility (CMR). Since the last review, FCCC has implemented a formal review mechanism to evaluate and prioritize its CCSG Shared Research Resources. As a result, of this evaluation process, the number of Shared Research Resources has been streamlined.