Administrative Core

宾夕法尼亚大学跟腱病变研究翻译中心(AT-CORT)将 促进基础发现研究，以指导翻译，以及使用和开发翻译 资源、模型和技术，以应对高度重要的研究和尚未满足的临床挑战 跟腱病。尽管肌腱病在年轻人和老年人中的频率很高，患病率也在不断上升 患者一样，显著的疼痛和残疾，以及相关的高昂的社会成本，评估和 有效的治疗方式的发展因缺乏关于 肌腱病因学和发病机制的力学生物学。在宾夕法尼亚大学，我们是唯一的 定位于具有浓厚兴趣和专业知识的多学科科学家和临床医生 这些领域和相关领域。该中心的工作将从细胞核、细胞、组织到活体 以动物模型和活体人类受试者为对象，以协调一致的方式在不同的尺度上进行引导 跟腱病的创新治疗方法。该中心的研究将发现基本的生理 指导翻译的流程。它还将作为确定角色的试验台，以及科学 和翻译的严密性，通过实施一种重复使用的跟腱病动物模型 激动人心的一系列体内纵向分析将在动物和人类受试者中并行进行。 该管理核心的具体目标是：目标1：为中心组件和 就中心当前或未来可能开展的活动向中心主任提出建议；目标2： 管理、评估和监测中心的组成部分和活动；目标3：沟通中心的 面向科学、临床和非专业团体的活动；目标4：管理试点和可行性补助金 方案及其相关的资金和报告；以及目标5：实施一项充实方案。《核心》 研究项目经过精心开发，在基础和应用之间架起了桥梁 具有高度互动性。在我们委员会结构(外部咨询、执行、 交流，丰富)，我们将调整我们的努力，以最有效的， 有效的，富有成效的方式可能。我们的试点和可行性补助计划将培养新的和 创新的项目方向符合我们的主题，并支持新技术的开发，以 带到我们的项目和翻译我们的努力。我们的方法将作为其他 肌腱和其他肌肉骨骼疾病，我们将在这些努力的基础上再接再厉。一个组织严密、 结构良好的行政核心对于实现中心的高度 跨学科和互动的研究项目和核心，并最大限度地提高研究活动、效率、 生产力、沟通和最终有影响力的转化，将我们的努力转化为科学和普普通通 社区。

The Achilles Tendinopathy Center of Research Translation (AT-CORT) at the University of Pennsylvania will foster fundamental discovery research to guide translation, as well as employ and develop translational resources, models and technologies, to address the highly significant research and unmet clinical challenge of Achilles tendinopathy. Despite the high frequency and increasing prevalence of tendinopathy to young and old patients alike, the significant pain and disability, as well as the associated high cost to society, evaluation and development of effective treatment modalities is hindered by the lack of fundamental guiding data on the mechanobiology of tendon etiology and pathogenesis. At the University of Pennsylvania, we are uniquely positioned with a critical mass of multidisciplinary scientists and clinicians with strong interest and expertise in these and related areas. The Center’s efforts will span from the nucleus, to the cell, to the tissue, to in vivo animal models and to living human subjects in a coordinated “back-and-forth” manner across scales to guide innovative approaches to Achilles tendinopathy. The Center’s research will discover fundamental physiologic processes to guide translation. It will also as serve as a test bed for defining the role, as well as the scientific and translational rigor, of a repetitive use Achilles tendinopathy animal model through implementation of an exciting series of in vivo longitudinal assays to be conducted in parallel in both animal and human subjects. The Specific Aims of this Administrative Core are to: Aim 1: Provide leadership for Center components and activities and advise the Center Director regarding current or potential future activities of the Center; Aim 2: Manage, evaluate and monitor the Center components and activities; Aim 3: Communicate the Center’s activities to the scientific, clinical, and lay communities; Aim 4: Administer the Pilot and Feasibility Grant Program and its associated funding and reporting; and Aim 5: Implement an Enrichment Program. The Core and Research Projects have been carefully developed in concert to bridge the fundamental and applied while being highly interactive. With regular guidance from our Committee structure (External Advisory, Executive, Communication, Enrichment), we will adapt our efforts to address our translational theme in the most efficient, effective, and productive manner possible. Our Pilot and Feasibility Grant program will foster new and innovative project directions consistent with our theme as well as support development of novel technologies to bring to our projects and for translation of our efforts. Our approach will serve as a critical paradigm for other tendon and indeed other musculoskeletal disorders and we will build on these efforts. A well organized and well-structured Administrative Core is absolutely essential to accomplish the Aims of the Center’s highly interdisciplinary and interactive Research Projects and Core, and to maximize research activity, efficiency, productivity, communication, and ultimate impactful translation of our efforts to the scientific and lay community.