Predictors of Alcohol Recovery and Relapse Among Female Drunk Drivers

这个指导研究科学家发展奖将准备候选人的职业目标集中 关于遗传和环境因素的相互作用，因为它们影响妇女的缓解和复发 酒精使用障碍和他们后代的酒精和药物使用过程。候选人的 近期的职业目标是：（1）精通设计和进行临床，包括 观察，研究，（2）获得对酒精使用障碍的遗传影响的知识， 分子遗传学，（3）定义酒精使用表型和相关的环境措施，用于 研究遗传和环境对妇女康复和复发的影响，以及（4）发展 在统计遗传学和结构方程建模方面的高级定量技能。研究计划是 旨在描述酒精使用模式，并检查缓解和复发的预测因素， 严重酒精使用障碍的女性，在一项高风险家庭研究数据的二次分析中， 酒精中毒（酒精中毒遗传学合作研究[COGA]）和新的数据将从 因酒后驾车而被定罪的妇女。新的数据收集将提供 候选人具有从事研究的经验， 这是实现招募后代和收集DMA长期目标的重要第一步。酒精 使用表型和环境影响，可以最大限度地提高检查基因-环境的能力 相互作用，因为它影响妇女的缓解和复发将被定义通过仔细整合， 研究和培训计划，利用COGA和Twin的新数据和二次分析数据， 样品可通过中西部酒精中毒研究中心获得。华盛顿大学 精神病学系和中西部酒精中毒研究中心提供了一个培训环境， 获得具有精神病遗传流行病学、统计学和分子遗传学专业知识的导师。 此外，候选人还获得了具有临床和治疗专业知识的共同导师的帮助 研究和与DUI人群合作。 相关性（参见说明）： 妇女对酒精的依赖对妇女及其子女产生深远的影响。有 有证据表明，今天的年轻女性比年长的女性更容易依赖酒精。 然而，大多数酒精研究都集中在男性身上。本研究将特别关注 更好地了解环境和遗传因素如何导致女性饮酒， 帮助他们康复，改善他们和他们的孩子的生活。

This Mentored Research Scientist Development Award will prepare the Candidate for career goals focused on the interplay of genetic and environmental factors as they influence remission and relapse among women with alcohol use disorders and the course of alcohol and drug use among their offspring. The Candidate's immediate career goals are to: (1) become proficient in designing and conducting clinical, including observational, research, (2) gain knowledge of genetic influences on alcohol use disorders and training in molecular genetics, (3) define alcohol use phenotypes and associated environmental measures for use in examining genetic and environmental influences on recovery and relapse among women, and (4) develop advanced quantitative skills in statistical genetics and structural equation modeling. The research plan is designed to characterize patterns of alcohol use and to examine predictors of remission and relapse among women with severe alcohol use disorders, in secondary analysis of data from a high-risk family study of alcoholism (Collaborative Study on the Genetics of Alcoholism [COGA]) and in new data to be collected from women with convictions for driving under the influence of alcohol (DUI). New data collection will provide the Candidate with experience in engaging in research a population that is historically difficult to locate and retain, an important first step towards the long-term goal of enrolling offspring and collecting DMA.Alcohol use phenotypes and environmental influences which can maximize the ability to examine gene-environment interplay as it influences women's remission and relapse will be defined through careful integration of the research and training plans, utilizing new data and secondary analysis of data from COGA and from twin samples available through the Midwest Alcoholism Research Center. The Washington University Department of Psychiatry and the Midwest Alcoholism Research Center provide a training environment with access to mentors with expertise in psychiatric genetic epidemiology and statistical and molecular genetics. In addition, the Candidate has enlisted the help of co-mentorswith expertise in clinical and treatment research and in working with DUI populations. RELEVANCE (See instructions): Alcohol dependence among women has profound consequences on women and on their children. There is evidence that today's young women are more likely to become dependent on alcohol than women of older generations, yet most alcohol research is focused on men. This research study will focus specifically on women to better understand how environmental and genetic factors contribute to women's alcohol use and to their recovery, and to improved outcomes for them and their children.