Predictors of Alcohol Recovery and Relapse Among Female Drunk Drivers

这一指导研究科学家发展奖将为候选人的职业目标重点 论影响女性缓解和复发的遗传和环境因素的相互作用 在他们的后代中有酒精使用障碍和酒精和药物使用的过程。候选人的 近期的职业目标是：(1)精通临床设计和实施，包括 观察、研究，(2)了解遗传对酒精使用障碍的影响，并在 分子遗传学，(3)定义酒精使用表型和相关的环境措施，用于 检查遗传和环境对妇女康复和复发的影响，以及(4)发展 掌握统计遗传学和结构方程建模方面的高级量化技能。研究计划是 旨在描述酒精使用的模式，并检查缓解和复发的预测因素 患有严重酒精使用障碍的妇女，在对来自高风险家庭研究的数据进行二次分析中 酒精中毒(酒精中毒遗传学合作研究[COGA])和将收集的新数据 因酒后驾车被定罪的女性(酒后驾车)。新的数据收集将提供 有从事研究的经验的候选人，历史上很难找到和 保留，朝着招收后代和收集DNA酒精这一长期目标迈出了重要的第一步 利用表型和环境影响，最大限度地提高检测基因环境的能力 影响妇女缓解和复发的相互作用将通过仔细整合 研究和培训计划，利用新数据和对COGA和TWINE数据的二次分析 样本可通过中西部酒精中毒研究中心获得。华盛顿大学 精神病学系和中西部酒精中毒研究中心提供培训环境 获得在精神病学、遗传流行病学、统计学和分子遗传学方面具有专业知识的导师。 此外，候选人还获得了在临床和治疗方面具有专业知识的合作导师的帮助 在研究和处理酒后驾车人群方面。 相关性(请参阅说明)： 妇女对酒精的依赖对妇女及其子女产生了深远的影响。的确有 有证据表明，当今的年轻女性比老年女性更容易对酒精产生依赖 然而，大多数酒精研究都集中在男性身上。这项研究将专门集中在 让女性更好地了解环境和遗传因素是如何导致女性饮酒的 为他们的康复以及为他们和他们的孩子改善结果。

This Mentored Research Scientist Development Award will prepare the Candidate for career goals focused on the interplay of genetic and environmental factors as they influence remission and relapse among women with alcohol use disorders and the course of alcohol and drug use among their offspring. The Candidate's immediate career goals are to: (1) become proficient in designing and conducting clinical, including observational, research, (2) gain knowledge of genetic influences on alcohol use disorders and training in molecular genetics, (3) define alcohol use phenotypes and associated environmental measures for use in examining genetic and environmental influences on recovery and relapse among women, and (4) develop advanced quantitative skills in statistical genetics and structural equation modeling. The research plan is designed to characterize patterns of alcohol use and to examine predictors of remission and relapse among women with severe alcohol use disorders, in secondary analysis of data from a high-risk family study of alcoholism (Collaborative Study on the Genetics of Alcoholism [COGA]) and in new data to be collected from women with convictions for driving under the influence of alcohol (DUI). New data collection will provide the Candidate with experience in engaging in research a population that is historically difficult to locate and retain, an important first step towards the long-term goal of enrolling offspring and collecting DMA.Alcohol use phenotypes and environmental influences which can maximize the ability to examine gene-environment interplay as it influences women's remission and relapse will be defined through careful integration of the research and training plans, utilizing new data and secondary analysis of data from COGA and from twin samples available through the Midwest Alcoholism Research Center. The Washington University Department of Psychiatry and the Midwest Alcoholism Research Center provide a training environment with access to mentors with expertise in psychiatric genetic epidemiology and statistical and molecular genetics. In addition, the Candidate has enlisted the help of co-mentorswith expertise in clinical and treatment research and in working with DUI populations. RELEVANCE (See instructions): Alcohol dependence among women has profound consequences on women and on their children. There is evidence that today's young women are more likely to become dependent on alcohol than women of older generations, yet most alcohol research is focused on men. This research study will focus specifically on women to better understand how environmental and genetic factors contribute to women's alcohol use and to their recovery, and to improved outcomes for them and their children.