Improving Research Capacity in Cameroon for Studies on HIV-Associated Malignancie

描述(申请人提供)：在非洲国家，与艾滋病相关的恶性肿瘤和其他病毒相关肿瘤的负担显著增加。然而，随着最近抗逆转录病毒治疗(ART)的扩大，HIV相关恶性肿瘤的流行病学、治疗和临床结果正在迅速演变。在喀麦隆，艾滋病毒感染者的癌症发病率稳步上升。大多数艾滋病毒或HLV相关癌症患者仍然无法获得或无法获得抗逆转录病毒治疗。在喀麦隆建设与艾滋病毒有关的控制能力至关重要。需要提供培训和设施，以便早期诊断和治疗，以便有效地控制艾滋病毒-癌症。有必要通过教授基本的预防保健措施来提高喀麦隆民众对艾滋病毒和艾滋病毒相关癌症的认识。为此，研究和临床人员必须接受培训，以识别早期迹象和症状，并整合艾滋病毒-癌症控制活动。该计划的目标是建立可持续的研究能力，在喀麦隆的机构研究艾滋病毒和艾滋病毒相关的恶性肿瘤，并提供源源不断的创新科学教育。与我们合作的机构的项目将加强科学知识和技能，加强对感染艾滋病毒相关恶性肿瘤患者的预防、诊断、治疗和护理。我们的多学科方法将侧重于对医生、实验室技术人员、护士、社会工作者和基础科学家的研究培训。我们的做法对于我们预防艾滋病毒传播和减轻喀麦隆受感染患者的疾病负担的目标至关重要。为了实现我们的主要目标，我们提出：目标1：在喀麦隆建立关键的生物医学、实验室和临床科学专业知识；目标2：促进旨在预防、诊断和治疗艾滋病毒及其相关恶性肿瘤的新研究工作；目标3：在NYUSoM和喀麦隆科学家之间建立长期合作关系；以及目标4：将培训纳入喀麦隆正在进行的预防、诊断和治疗研究工作。相关性：该方案将导致卫生工作者的能力建设和科学丰富，以此作为防止艾滋病毒和艾滋病毒相关恶性肿瘤进一步发展的一种方式。

DESCRIPTION (provided by applicant): There has been a significant increase in the burden of AIDS-related malignancies and other virus- associated tumors in the countries of Africa. However, with the recent expanded access of antiretroviral therapy (ART), the epidemiology, treatment and clinical results of HIV-associated malignancies are rapidly evolving. In Cameroon, the incidence of cancers in patients with HIV infection has increased steadily. Treatment and use of ART still remain unavailable or inaccessible to most patients with HIV or HlV-related cancers. Building HIV-associated control capacity in Cameroon is critical. There is a need for the provision of training and of facilities for early diagnosis and treatment for effective HIV-cancer associated control. There is a need to increase the awareness of the population in Cameroon about HIV and HIV-associated cancers by teaching basic preventive health measures. For this, research and clinical personnel have to be trained to recognize the early signs and symptoms and integrate HIV-cancer control activities. The goal of this program is to build a sustainable research capacity to study HIV and HIV-associated malignancies at institutions in Cameroon and to provide a steady flow of innovative science-based education. The programs at the institutions with which we partner will strengthen scientific knowledge and skills, enhancing prevention, diagnosis, treatment and care for patients infected with HIV-associated malignancies. Our multidisciplinary approach will be focused on research training for physicians, laboratory technicians, nurses, social workers, and basic scientists. Our approach is crucial to our goal of preventing HIV transmission and reducing the burden of disease on the infected patients in Cameroon. In order to accomplish our main goal we propose: Aim # 1: To establish critical biomedical, laboratory and clinical science expertise in Cameroon; Aim # 2: To facilitate new research efforts aimed at prevention, diagnosis and treatment of HIV and HIV- associated malignancies; Aim # 3: To establish long-term collaborative relationships between NYUSoM and scientists in Cameroon; and. Aim # 4: To integrate the training into ongoing prevention, diagnosis and treatment research efforts in Cameroon. RELEVANCE: This program will lead to the capacity building and scientific enrichment of health workers as a way to prevent HIV and HIV associated malignancies from progressing further.