Multidisciplinary Clinical and Translational Science (MCTS) Program (TL1)

为什么没有更多的人成功地将激动人心的科学发现转化为更好的病人 保健和社区保健（1，2）？可能的解释包括临床研究人员的短缺和高流动率 由于体制和环境支持不足（3）;不愿放弃传统的 以部门为中心的研究和培训模式;缺乏有效的教育博士科学家关于 人类健康和疾病的生理学和病理生理学（4）;以及在提供临床和实验室方面的差距 拥有在当前研究环境中取得成功所需工具的科学家，包括 跨学科团队在本节中，我们提出了这些可能的障碍的解决方案，并提供了一个 实施计划是可实现的，可以评估。 我们的CTSA应用程序的这一关键组件的总体目标是创建下一代临床 代表多个学科的研究人员将成为边界专家，能够传播新的想法， 连接不同学科的实验室和研究人员。 西北大学几十年来一直致力于跨学科研究。它提供了激励措施 包括教师职位和研究资金，以打破学科之间的界限和障碍， 将生命科学和工程领域基于学科的研究生培训计划合并为4个综合项目， 跨校园地点的项目。我们建议在已经成功的计划的基础上再接再厉， 跨学科研究教育，培训和职业发展，建立临床中心， 研究教育（CCRE）。该中心将协调和加强现有的临床和翻译 研究教育，培训和职业发展活动;创建新的课程，研讨会和计划 并将其与现有活动相结合;通过包括博士预科课程来扩大我们课程的候选人库 培训人员和基础科学家;采用与过去不同的方式教育/培训候选人， 扩大课程设置和研讨会，建立跨学科团队，并培养 培训人员使用精心挑选的导师和新的监督程序，包括标准化的跟踪工具。 该中心还将为临床研究和监管人员以及社区提供新的机会 investigators.该中心及其主要项目将由一个充满活力和经验丰富的领导团队领导。

Why have there.not been more successes in translating exciting scientific discoveries into improved patient care and community health (1,2)? Possible explanations include a shortage and high turnover rate of clinicianinvestigators due to insufficient institutional and environmental support (3); reluctance to let go of the traditional department-centric research and training models; a lack of effectiveness in educating PhD scientists about the physiology and pathophysiology of human health and disease (4); and a gap in providing clinical and bench scientists with the tools needed to be successful in the current research environment, including working in interdisciplinary teams. In this section we propose solutions to these possible barriers and provide an implementation plan that is achievable and can be evaluated. The overall goal of this key component of our CTSA application is to create the next generation of clinical researchers representing multiple disciplines who will be boundary spanners, able to pollinate new ideas and link laboratories and investigators in different disciplines. Northwestern University has fostered interdisciplinary research for several decades. It has provided incentives including faculty positions and research funding to break the lines and barriers separating disciplines, and merged discipline-based graduate training programs in the life sciences and engineering into 4 integrated programs that span campus locations. We propose building on an already successful program of interdisciplinary research education, training and career development by establishing the Center for Clinical Research Education (CCRE). The Center will coordinate and enhance existing clinical and translational research education, training and career development activities; create new courses, seminars and programs and integrate them with existing activities; expand the candidate pool for our programs by including predoctoral trainees and .basic scientists; educate/train the candidates differently than in the past using an expanded set of course offerings and seminars and established interdisciplinary teams, and nurture the trainees using carefully chosen mentors and new oversight procedures including standardized tracking tools. The Center will also provide new opportunities for clinical research and regulatory staff and community investigators. The Center and its key programs will be led by a dynamic and experienced leadership team.