Research Fellowship in Geriatric Mood Disorders

描述（由申请人提供）：这是T32威尔-康奈尔老年情绪障碍研究奖学金项目的第五个竞争申请，该项目已经提供了20年的多学科培训。从概念上讲，我们认为情绪障碍是异质性的，其病因包括遗传因素、衰老和疾病相关的生物学变化、残疾和社会心理因素。在方法上，我们在患者、实践和社区层面教授生物评估技术以及纵向设计和临床驱动的干预措施。这种方法已经在有巨大健康和心理健康需求的人群中进行了转化研究。项目的优势在于：1)学员的学习成绩；过去10年培训的17名研究员获得22项资助，共同发表论文101篇（第一作者41篇）；2)领导国家层面的研究培训（NIMH暑期研究所和高级研究所的pi）；3) NIMH资助的转化研究人员，包括分子遗传学、神经影像学、临床药理学、干预开发和精神卫生服务研究；4)康奈尔大学ACISR的凝聚力组织；5)试点项目5个；6)丰富的研究人群和实验室资源；7)可供研究员进行二次分析和假设的数据库；8)与老年医学、普通内科、临床流行病学和服务研究项目、公共卫生和医学伦理研究人员长期有效合作；9)领导8项多地点研究。该项目将由临床生物学（G. Alexopoulos）和卫生服务研究（M. Bruce）方面的研究人员指导，他们在研究培训方面有着良好的记录，并由一个在分子遗传学、神经成像和治疗开发方面具有专业知识的执行委员会指导。我们要求每年支持2名学员，他们的个性化培训计划将由两名导师（例如一名临床和一名基础研究员或一名服务和一名临床研究员）协调，以促进翻译研究。除了核心课程之外，我们还指导和支持学员进行自己的研究，准备有竞争力的资金申请，以及发表基于数据的论文。

DESCRIPTION (provided by applicant): This is the fifth competing application of the T32 Weill-Cornell Research Fellowship Program in Geriatric Mood Disorders, which has been offering multidisciplinary training for 20 years. Conceptually, we view mood disorders as heterogeneous with etiological contributions from genetic factors, aging- and disease-related biological changes, disability, and psychosocial factors. Methodologically, we teach biological assessment techniques as well as longitudinal designs and clinically-driven interventions at the patient, the practice, and the community levels. This approach has led to translational studies in a population with great health and mental health needs. The Program's strengths are: 1) The academic record of its trainees; the 17 fellows trained of the past 10 years received 22 grants and coauthored 101 papers (41 first-authored); 2) Leadership in research training at a national level (PIs of the NIMH Summer Research Institute and the Advanced Research Institute); 3) NIMH- funded faculty in translational research ranging from molecular genetics, neuroimaging, clinical pharmacology, intervention development, and mental health services research; 4) Cohesive organization of the Cornell ACISR; 5) Five pilot project programs; 6) Rich study populations and laboratory resources; 7) Databases available for secondary analyses and hypothesis generation by the fellows; 8) Long and effective collaboration with investigators of Geriatric Medicine, General Internal Medicine, Clinical Epidemiology and Services Research Program, Public Health and Medical Ethics; and 9) Leadership in 8 multisite studies. The Program will be directed by funded investigators in clinical biology (G. Alexopoulos) and health services research (M. Bruce) with a strong record in research training and by an Executive Committee with expertise in molecular genetics, neuroimaging, and treatment development. We request support for 2 trainees per year, whose individualized training programs will be coordinated by two preceptors (e.g. one clinical and one basic investigator or one services and one clinical investigator) to facilitate translation research. Beyond a Core Curriculum, we guide and support our trainees in conducting their own research studies, in preparing competitive funding applications, and in publishing data-based papers.