课题基金 / 基金详情

Malaria Drug Resistance and Disease Virulence

Malaria Drug Resistance and Disease Virulence
疟疾耐药性和疾病毒力
批准号：
8745299
负责人：
Thomas E Wellems
金额：
$134.93万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8745299
关键词：
AfricaAntimalarialsAreaAsiaCessation of lifeDevelopmentDiagnosticDiagnostic testsDiseaseDrug resistanceGenesHumanInfectionInvestigationKnowledgeLaboratoriesMalariaModelingParasitesPlasmodium falciparumPlasmodium vivaxPrimatesProcessResearchResearch ActivityResearch Project GrantsResistanceSouth AmericaTestingVaccinesVirulencechemotherapydisabilitydrug candidatefield studyimprovedmultidisciplinarynovel diagnosticsnovel therapeutic interventionprogramsresponsetoolvaccine candidate

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中文摘要
翻译
我们的研究项目侧重于疟疾寄生虫如何对主要抗疟疾药物产生耐药性，以及为什么导致人类疟疾致残和死亡的两个物种（恶性疟原虫和间日疟原虫）的菌株对人类和其他灵长类动物表现出不同的传染性。在这些研究领域，我们寻求能够改进对疟疾疾病过程的认识的进展，从而支持开发或测试新的抗疟疾化疗、诊断工具和疫苗。我们项目的研究活动是多学科的，包括在非洲、亚洲和南美洲疟疾地区的实地研究，以及基础实验室调查项目。
英文摘要
Our research project focuses on how malaria parasites become resistant to major antimalarial drugs and why strains of the two species responsible most human malaria disability and death (Plasmodium falciparum and Plasmodium vivax) show different infectivities to humans and other primates. In these areas of research, we seek advances that can improve the knowledge of disease processes in malaria and thereby support the development or testing of new antimalarial chemotherapies, diagnostic tools, and vaccines. The research activities in our program are multidisciplinary and include field studies in malarious regions of Africa, Asia and South America, as well as programs of basic laboratory investigation.
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Malaria Pathogenesis and Clinical Immunity
Malaria Drug Resistance and Disease Virulence
Biochemical And Biophysical Parasitology
Dry Season Ecology of Malaria Vectors
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