ASPEN 2013 Research Workshop: The Interface between Nutrition and the Gut Microbi

描述（由申请人提供）：美国肠外和肠内营养学会（白杨）研究研讨会（RW）是一个非常成功和科学上受人尊敬的会议，汇集了致力于发展循证临床实践的营养研究人员和临床医生，确保尖端的患者护理。白杨2013 RW侧重于肠道微生物菌群（即肠道微生物组）与人类健康之间的相互作用，特别是当它转化为患者的临床护理时。 人类基因组的阐明导致了关于人类微生物组和肠道微生物及其基因之间的界面以及人类健康的知识的广泛收获。长期以来，人们已经认识到宿主的营养状况和营养摄入在肠道微生物菌群的组成中起着关键作用，营养基因组学、代谢组学和相关领域的发展使我们对这种关键相互作用的理解不断完善。特别是，营养物质的途径和组成对肠道微生物组的特征和功能具有巨大的影响，而肠道微生物组又在炎症状态中起关键作用，包括全身炎症反应综合征、肠粘膜疾病和缺血/再灌注损伤。肠道微生物菌群和危重病之间的这种相互作用与危重病患者的营养支持和管理特别相关，并且白杨临床医生和研究人员对此非常感兴趣。白杨2013 RW“营养与肠道微生物组之间的界面：对人类健康的影响和应用”既及时又新颖，因为它专注于将科学状态转化为患者护理。该RW将为跨学科思维和跨临床营养和代谢领域的研究人员和临床医生之间的互动提供一个强大的场所，共同完善推进这一新兴领域的研究议程。 白杨2013 RW的具体目标包括：1）吸引不同的科学家，演讲者和与会者，他们对肠道微生物组有共同的兴趣，因为它与临床营养和代谢研究有关。2）通过促进跨学科研究人员之间的交流和合作来支持转化科学，这些跨学科研究人员包括基础科学家、临床试验者以及能够应用他们的发现的临床医生。3)到 为早期职业研究人员提供指导机会。4)促进赠款提案的制定，目的是在临床或实验室环境中测试关于营养和肠道微生物组的新假设。5)向更广泛的科学界传播2013年RW活动和信息。2013年关于营养和肠道微生物组的研讨会将在实现本提案中概述的具体目标方面取得巨大成功，以先前研讨会为基础，并提供对营养支持和患者护理科学进步至关重要的多学科场所。1

DESCRIPTION (provided by applicant): The American Society for Parenteral and Enteral Nutrition (ASPEN) Research Workshop (RW) has been a highly successful and scientifically respected conference that brings together nutrition researchers and clinicians committed to the development of evidence-based clinical practices ensuring cutting-edge patient care. The ASPEN 2013 RW focuses on the interplay between the intestinal micro-flora (i.e. the gut micro-biome) and human health, particularly as it translates to the clinical care of patients. The elucidation of the human genome has led to expansive gains in knowledge regarding the human micro-biome and the interface between intestinal microbes and their genes, and human health. It has long been recognized that the nutritional status and nutrient intake of the host plays a pivotal role in the composition of the intestinal micro-flora, and the development of nutria-genomics, metabolomics, and related fields has led to continued refinement of our understanding of this critical interplay. In particular, the route and composition of nutrient intae has tremendous implications to the characteristics and function of the gut micro-biome, which in turn plays a critical role in inflammatory states, including systemic inflammatory response syndrome, intestinal mucosal diseases, and ischemia/reperfusion injury. This interplay between the intestinal micro-flora and critical illness has particular relevance to the nutrition support ad management of critically ill patients, and is of significant interest to ASPEN clinicians and researchers. The ASPEN 2013 RW "The Interface between Nutrition and the Gut Micro-biome: Implications and Applications for Human Health" is both timely and novel, in that it focuses on translating the state of the science to patient care. This RW will provide a powerful venue for interdisciplinary thinking and interaction between researchers and clinicians across the spectrum of clinical nutrition and metabolism to come together to refine the research agenda for advancing this emerging field. The specific aims of the ASPEN 2013 RW include: 1) to attract a diverse group of scientists, speakers and attendees with a common interest in the gut micro-biome as it relates to clinical nutrition and metabolic research. 2)to support translational scienc by fostering communication and collaboration among interdisciplinary researchers ranging from basic scientists to clinical trialists together with clinicians who can apply their findings. 3) to provide opportunities for mentorship of early career researchers. 4) to promote development of grant proposals with the aim of testing novel hypotheses on nutrition and the gut micro-biome in clinical or bench-top settings. 5) to disseminate the 2013 RW activities and information to the broader scientific community. The 2013 RW on Nutrition and the Gut Micro-biome is poised to be highly successful in achieving the specific aims outlined in this proposal, building on the foundation of prior workshops and providing the multidisciplinary venue so essential to the advancement of the science of nutrition support and patient care. 1