Personalized Bio-behavioral Weight Loss Intervention for African American Women

描述(由申请人提供)：这份K01指导研究科学家发展奖提案旨在为候选人提供必要的学术培训、指导和资源，以发展生物行为研究方面的专业知识。这位候选人的主要职业目标是成为肥胖预防/治疗领域的一名有资金的独立研究员和公认的领导者，拥有为非裔美国人(AA)女性开发个性化生物行为减肥干预措施的专业知识。为了实现这一目标，建议制定一项有重点的职业发展计划，以：1)获得了解基因变异如何与肥胖症相关的知识和技能；调节生活方式行为(如PA、饮食)对肥胖症变化的影响，以及这些基因型最终如何被用于帮助对肥胖的AA妇女进行个性化的行为干预；2)获得复杂量化研究方法的知识和技能，包括生物行为研究设计和分析以及高级干预开发；以及3)提高赠款和学术写作技能，并撰写手稿，同时继续与遗传学、肥胖症和预防研究领域的其他研究人员建立跨学科的合作。南卡罗来纳医科大学提供全面的培训环境，其中包括在生物行为干预、遗传学和健康差异研究方面拥有专业知识的资深科学家。候选人拥有一支强大的跨专业和跨机构的指导团队，在基于社区的随机对照试验(RCT)、遗传学、肥胖预防和治疗、生物行为干预、生物统计学和流行病学方面具有互补的专业知识。该研究计划建立在培训目标的基础上，直接响应国家护理研究所(NINR)整合生物和行为科学、利用新技术研究问题、改进研究方法和培养未来科学家的使命。这项研究的主要目标是确定在低社会经济地位(SES)肥胖的AA女性中开发有效的社会文化定制的行为干预措施以长期减肥的关键组成部分。社会文化偏好将被纳入行为改变战略、遗传信息的交流，以及调整循证糖尿病预防计划材料和方法的格式和交付，以促进减肥。为了实现这一目标，候选人将利用遗传数据库的二级数据分析进行一项探索性研究。其次，干预开发阶段，80名肥胖的再生障碍性贫血妇女居住在南卡罗来纳州查尔斯顿的公共住房社区，以整合遗传学的新知识和技能，同时提高生物行为研究干预开发和方法方面的技能。拟议的初步研究结果将为更大规模、充足动力和资源的社区提供信息，为肥胖的再障女性提供RCT，结合使用遗传信息和社会文化偏好来开出量身定制的减肥策略，并促进长期减肥结果。

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Development Award proposal is designed to provide the scholarly training, mentorship, and resources necessary for the candidate to develop expertise in bio-behavioral research. The candidate's primary career goal is to become a funded independent investigator and recognized leader in the field of obesity prevention/treatment with expertise in developing personalized bio-behavioral weight loss interventions for African American (AA) women. To achieve this goal, a focused career development plan is proposed to: 1) Obtain knowledge and skills in understanding how genetic variants may be related to adiposity; modulate influence of lifestyle behaviors (i.e.PA, diet) upon changes in adiposity, and how these genotypes may eventually be used to help personalize behavioral interventions for obese AA women; 2) Obtain knowledge and skills in complex quantitative research methods, including bio-behavioral research designs and analyses, and advanced intervention development; and, 3) Enhance grant and scholarly writing skills, and manuscript production while continuing to build interdisciplinary collaboration with other researchers in the field of genetics, obesity and prevention research. The Medical University of South Carolina provides a comprehensive training environment that includes senior scientists with expertise in bio-behavioral interventions, genetics, and health disparities research. The candidate has a strong inter-professional and inter-institutional mentoring team with complementary expertise in the development of community based randomized controlled trials (RCT), genetics, obesity prevention and treatment, bio-behavioral interventions, biostatistics and epidemiology. The research plan, which builds on the training objectives, is directly responsive to the National Institute of Nursing Research's (NINR) mission of integrating the biological and behavioral sciences, employing new technologies to research questions, improving research methods, and developing the scientists of the future. The broad goal of this research is to identify key components for development of efficacious socio-culturally tailored behavioral interventions for long-term weight loss in low socioeconomic status (SES) obese AA women. The socio-cultural preferences will be incorporated into behavioral change strategies, the communication of genetic information, and the adaptation of the format and delivery of the evidence-based Diabetes Prevention Program materials and approaches to promote weight loss. To meet this goal, the candidate will conduct an exploratory study using genetic database secondary data analyses. Secondly, an intervention development phase, with 80 obese AA women living in public housing neighborhoods in the Charleston, SC region, to integrate new knowledge and skills from genetics while advancing skills in bio- behavioral research intervention development and methodology. The results of the proposed preliminary studies will inform a larger, adequately powered and resourced community based RCT for obese AA women that incorporates the use of genetic information and socio-cultural preferences to prescribe tailored weight loss strategies and promote long-term weight loss outcomes.