Human Tissue and Genomics Core

核心B 核心B的主要目标是为单个项目提供肠道组织、分离的细胞群和 来自临床特征的IBD患者和健康对照的功能基因组信息。这个核心将 克服广泛承认的动物模型使用障碍-指导动物研究以解决 可以直接翻译成人类IBD的问题。数据和组织库与新技术 通过这个核心的开发将使研究人员有机会将分子发现与 人类疾病的典范物种。核心B将利用北卡罗来纳大学的大量现有资源和专业知识。 在获取和处理手术切除和肠道活组织检查方面有一个既定的基础设施。 这个

Core B The primary goal of Core B is to provide individual projects with intestinal tissue, isolated cell populations, and functional genomic information from clinically characterized IBD patients and healthy controls. This core will overcome a widely acknowledged roadblock in the use of animal models - directing animal research to address questions that will be directly translatable to human IBD. The data and tissue banks and novel technologies developed through this core will allow investigators the opportunity to correlate molecular findings across model species to human diseases. Core B will leverage substantial existing resources and expertise at UNC. There is an established infrastructure for obtaining and processing surgical resections and intestinal biopsies. The